Nobiletin in Cancer Therapy: How This Plant Derived-Natural Compound Targets Various Oncogene and Onco-Suppressor Pathways
Open Access
- 5 May 2020
- journal article
- review article
- Published by MDPI AG in Biomedicines
- Vol. 8 (5), 110
- https://doi.org/10.3390/biomedicines8050110
Abstract
Cancer therapy is a growing field, and annually, a high number of research is performed to develop novel antitumor drugs. Attempts to find new antitumor drugs continue, since cancer cells are able to acquire resistance to conventional drugs. Natural chemicals can be considered as promising candidates in the field of cancer therapy due to their multiple-targeting capability. The nobiletin (NOB) is a ubiquitous flavone isolated from Citrus fruits. The NOB has a variety of pharmacological activities, such as antidiabetes, antioxidant, anti-inflammatory, hepatoprotective, and neuroprotective. Among them, the antitumor activity of NOB has been under attention over recent years. In this review, we comprehensively describe the efficacy of NOB in cancer therapy. NOB induces apoptosis and cell cycle arrest in cancer cells. It can suppress migration and invasion of cancer cells via the inhibition of epithelial-to-mesenchymal transition (EMT) and EMT-related factors such as TGF-β, ZEB, Slug, and Snail. Besides, NOB inhibits oncogene factors such as STAT3, NF-κB, Akt, PI3K, Wnt, and so on. Noteworthy, onco-suppressor factors such as microRNA-7 and -200b undergo upregulation by NOB in cancer therapy. These onco-suppressor and oncogene pathways and mechanisms are discussed in this review.Keywords
Funding Information
- Department of Biotechnology, Ministry of Science and Technology, India (BT/RLF/Re-entry/24/2014)
This publication has 259 references indexed in Scilit:
- Characteristics of nobiletin-mediated alteration of gene expression in cultured cell linesBiochemical and Biophysical Research Communications, 2013
- Mechanism of chronic dietary iron overload-induced liver damage in miceMolecular Medicine Reports, 2013
- Multidrug Resistance Reversal and Apoptosis Induction in Human Colon Cancer Cells by Some Flavonoids Present in Citrus PlantsJournal of Natural Products, 2012
- Activating Nrf-2 Signaling Depresses Unilateral Ureteral Obstruction-Evoked Mitochondrial Stress-Related Autophagy, Apoptosis and Pyroptosis in KidneyPLOS ONE, 2012
- Antimetastatic effect of nobiletin through the down-regulation of CXC chemokine receptor type 4 and matrix metallopeptidase-9Pharmaceutical Biology, 2012
- Chronic intestinal inflammation: inflammatory bowel disease and colitis-associated colon cancerFrontiers in Immunology, 2012
- Targeting poly(ADP-ribose) polymerase activity for cancer therapyCellular and Molecular Life Sciences, 2010
- Dietary genistein negates the inhibitory effect of letrozole on the growth of aromatase-expressing estrogen-dependent human breast cancer cells (MCF-7Ca) in vivoCarcinogenesis: Integrative Cancer Research, 2008
- Pinitol targets nuclear factor-κB activation pathway leading to inhibition of gene products associated with proliferation, apoptosis, invasion, and angiogenesisMolecular Cancer Therapeutics, 2008
- Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesisOncogene, 2002