Role of cyclosporin 0.1% in perennial vernal keratoconjunctivitis

Abstract

Introduction To evaluate the efficacy of topical cyclosporin A 0.1% eye drops in management of moderate to severe perennial vernal keratoconjunctivitis. Methods Fourteen patients with moderate to severe perennial vernal keratoconjunctivitis, who were dependent on steroid eye drops for control of disease, were administered 0.1% cyclosporin A eye drops twice a day. Signs, symptoms and steroid score were calculated at start of study, and then at two monthly interval. Results Ten males and four females, between age of 3 – 17 years were enrolled in this study. Treatment with cyclosporin A 0.1% eye drops decreased the symptom, sign and steroid score at 12 months (p<0.0001, paired t test). Steroid sparing effect was seen in five patients at the end of study period. Conclusions Topical cyclosporin A 0.1% eye drops can be used as a steroid sparing agent in the management of perennial vernal keratoconjunctivitis.