Biofabrication offers future hope for tackling various obstacles and challenges in tissue engineering and regenerative medicine: A Perspective
Open Access
- 13 December 2018
- journal article
- research article
- Published by AccScience Publishing in International Journal of Bioprinting
- Vol. 5 (1), 153
- https://doi.org/10.18063/ijb.v5i1.153
Abstract
Biofabrication is an emerging multidisciplinary field that makes a revolutionary impact on the researches on life science, biomedical engineering, and both basic and clinical medicine, has progressed tremendously over the past few years. Recently, there has been a big boom in three-dimensional (3D) printing or additive manufacturing (AM) research worldwide, and there is a significant increase not only in the number of researchers turning their attention to AM but also publications demonstrating the potential applications of 3D printing techniques in multiple fields. Biofabrication and bioprinting hold great promise for the innovation of engineering-based organ replacing medicine. In this mini review, various challenges in the field of tissue engineering are focused from the point of view of the biofabrication - strategies to bridge the gap between organ shortage and mission of medical innovation research seek to achieve organ-specific treatments or regenerative therapies. Four major challenges are discussed including (i) challenge of producing organs by AM, (ii) digitalization of tissue engineering and regenerative medicine, (iii) rapid production of organs beyond the biological natural course, and (iv) extracorporeal organ engineering.Keywords
This publication has 104 references indexed in Scilit:
- 3D Bioprinting of heterogeneous aortic valve conduits with alginate/gelatin hydrogelsJournal of Biomedical Materials Research Part A, 2012
- Transplantation of an allogeneic vein bioengineered with autologous stem cells: a proof-of-concept studyThe Lancet, 2012
- Bioprinting of a mechanically enhanced three-dimensional dual cell-laden construct for osteochondral tissue engineering using a multi-head tissue/organ building systemJournal of Micromechanics and Microengineering, 2012
- An algorithm-based topographical biomaterials library to instruct cell fateProceedings of the National Academy of Sciences of the United States of America, 2011
- An cell-assembly derived physiological 3D model of the metabolic syndrome, based on adipose-derived stromal cells and a gelatin/alginate/fibrinogen matrixBiomaterials, 2010
- Design and analysis of digital materials for physical 3D voxel printingRapid Prototyping Journal, 2009
- In Vitro Angiogenesis of 3D Tissue Engineered Adipose TissueJournal of Bioactive and Compatible Polymers, 2009
- The pregnant sheep as a model for human pregnancyTheriogenology, 2008
- Generation of Three-Dimensional Hepatocyte/Gelatin Structures with Rapid Prototyping SystemTissue Engineering, 2006
- Tissue EngineeringScience, 1993