Regulation of Resistance in Vancomycin-Resistant Enterococci: The VanRS Two-Component System
Open Access
- 25 September 2021
- journal article
- review article
- Published by MDPI AG in Microorganisms
- Vol. 9 (10), 2026
- https://doi.org/10.3390/microorganisms9102026
Abstract
Vancomycin-resistant enterococci (VRE) are a serious threat to human health, with few treatment options being available. New therapeutics are urgently needed to relieve the health and economic burdens presented by VRE. A potential target for new therapeutics is the VanRS two-component system, which regulates the expression of vancomycin resistance in VRE. VanS is a sensor histidine kinase that detects vancomycin and in turn activates VanR; VanR is a response regulator that, when activated, directs expression of vancomycin-resistance genes. This review of VanRS examines how the expression of vancomycin resistance is regulated, and provides an update on one of the field’s most pressing questions: How does VanS sense vancomycin?Keywords
Funding Information
- National Institutes of Health (1R01AI148679)
This publication has 253 references indexed in Scilit:
- Identification of VanN-Type Vancomycin Resistance in an Enterococcus faecium Isolate from Chicken Meat in JapanAntimicrobial Agents and Chemotherapy, 2012
- d -Ala- d -Ser VanN-Type Transferable Vancomycin Resistance in Enterococcus faeciumAntimicrobial Agents and Chemotherapy, 2011
- Negative control in two-component signal transduction by transmitter phosphatase activityMolecular Microbiology, 2011
- Two-Component Systems and Their Co-Option for Eukaryotic Signal TransductionCurrent Biology, 2011
- Membrane domain structures of three classes of histidine kinase receptors by cell-free expression and rapid NMR analysisProceedings of the National Academy of Sciences of the United States of America, 2010
- Evolution and phyletic distribution of two-component signal transduction systemsCurrent Opinion in Microbiology, 2010
- Molecular Characterization of Enterococcus faecalis N06-0364 with Low-Level Vancomycin Resistance Harboring a Novel d -Ala- d -Ser Gene Cluster, vanLAntimicrobial Agents and Chemotherapy, 2008
- Crystal Structure of a Functional Dimer of the PhoQ Sensor DomainOnline Journal of Public Health Informatics, 2008
- Domain Orientation in the Inactive Response Regulator Mycobacterium tuberculosis MtrA Provides a Barrier to Activation,Biochemistry, 2007
- VanG-Type Vancomycin-Resistant Enterococcus faecalis Strains Isolated in CanadaAntimicrobial Agents and Chemotherapy, 2006