Eosinophilic gastrointestinal disorders and allergen immunotherapy: Lights and shadows
- 27 January 2021
- journal article
- review article
- Published by Wiley in Pediatric Allergy and Immunology
- Vol. 32 (5), 814-823
- https://doi.org/10.1111/pai.13458
Abstract
Allergic diseases, such as IgE‐mediated food allergy, asthma and allergic rhinitis, are relevant health problems worldwide and show an increasing prevalence. Therapies for food allergies are food avoidance and the prompt administration of intramuscular epinephrine in anaphylaxis occurring after accidental exposure. However, allergen immunotherapy (AIT) is being investigated as a new potential tool for treating severe food allergies. Effective oral immunotherapy (OIT) and epicutaneous immunotherapy (EPIT) induce desensitization and restore immune tolerance to the causal allergen. While immediate side effects are well known, the long‐term effects of food AIT are still underestimated. In this regard, eosinophilic gastrointestinal disorders (EGIDs), mainly eosinophilic esophagitis, have been reported as putative complications of OIT for food‐allergy and sublingual immunotherapy (SLIT) for allergic asthma and rhinitis. Fortunately, these complications are usually reversible and the patient recovers after AIT discontinuation. This review summarizes current knowledge on the possible causative link between eosinophilic gastrointestinal disorders and AIT, highlighting recent evidence and controversies.Keywords
This publication has 78 references indexed in Scilit:
- Induction of Eosinophilic Esophagitis by Sublingual Pollen ImmunotherapyCase Reports in Gastroenterology, 2013
- Seasonal Distribution and Eosinophilic EsophagitisJournal of Clinical Gastroenterology, 2013
- Eosinophilic esophagitis in children and adolescents: epidemiology, clinical presentation and seasonal variationThe Esophagus, 2012
- Epicutaneous Immunotherapy (EPIT) Blocks the Allergic Esophago-Gastro-Enteropathy Induced by Sustained Oral Exposure to Peanuts in Sensitized MicePLOS ONE, 2012
- The Prevalence, Severity, and Distribution of Childhood Food Allergy in the United StatesPEDIATRICS, 2011
- Eosinophils in health and disease: the LIAR hypothesisClinical & Experimental Allergy, 2010
- Safety of a peanut oral immunotherapy protocol in children with peanut allergyJournal of Allergy and Clinical Immunology, 2009
- Relationships Between Eosinophilic Inflammation, Tissue Remodeling, and Fibrosis in Eosinophilic EsophagitisImmunology and Allergy Clinics of North America, 2009
- Dichotomy of food and inhalant allergen sensitization in eosinophilic esophagitisAllergy, 2007
- Is There a Seasonal Variation in the Incidence or Intensity of Allergic Eosinophilic Esophagitis in Newly Diagnosed Children?Journal of Clinical Gastroenterology, 2007