Impact of circadian disruption on glucose metabolism: implications for type 2 diabetes
Top Cited Papers
Open Access
- 8 January 2020
- journal article
- review article
- Published by Springer Science and Business Media LLC in Diabetologia
- Vol. 63 (3), 462-472
- https://doi.org/10.1007/s00125-019-05059-6
Abstract
The circadian system generates endogenous rhythms of approximately 24 h, the synchronisation of which are vital for healthy bodily function. The timing of many physiological processes, including glucose metabolism, are coordinated by the circadian system, and circadian disruptions that desynchronise or misalign these rhythms can result in adverse health outcomes. In this review, we cover the role of the circadian system and its disruption in glucose metabolism in healthy individuals and individuals with type 2 diabetes mellitus. We begin by defining circadian rhythms and circadian disruption and then we provide an overview of circadian regulation of glucose metabolism. We next discuss the impact of circadian disruptions on glucose control and type 2 diabetes. Given the concurrent high prevalence of type 2 diabetes and circadian disruption, understanding the mechanisms underlying the impact of circadian disruption on glucose metabolism may aid in improving glycaemic control.Keywords
This publication has 50 references indexed in Scilit:
- Adverse Metabolic Consequences in Humans of Prolonged Sleep Restriction Combined with Circadian DisruptionScience Translational Medicine, 2012
- Rotating Night Shift Work and Risk of Type 2 Diabetes: Two Prospective Cohort Studies in WomenPLoS Medicine, 2011
- Sleep Restriction for 1 Week Reduces Insulin Sensitivity in Healthy MenDiabetes, 2010
- Adverse metabolic and cardiovascular consequences of circadian misalignmentProceedings of the National Academy of Sciences of the United States of America, 2009
- Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretionNature Genetics, 2008
- Variants in MTNR1B influence fasting glucose levelsNature Genetics, 2008
- Social Jetlag: Misalignment of Biological and Social TimeChronobiology International, 2006
- Impact of sleep debt on metabolic and endocrine functionThe Lancet, 1999
- Modulation of glucose regulation and insulin secretion by circadian rhythmicity and sleep.JCI Insight, 1991
- Diurnal Variation of Oral Glucose Tolerance: a Possible Pointer to the Evolution of Diabetes MellitusBMJ, 1969