Comprehensive Lifestyle-Modification in Patients with Ulcerative Colitis–A Randomized Controlled Trial
Open Access
- 23 September 2020
- journal article
- research article
- Published by MDPI AG in Journal of Clinical Medicine
- Vol. 9 (10), 3087
- https://doi.org/10.3390/jcm9103087
Abstract
Patients with ulcerative colitis suffer from impaired health-related quality of life (HrQoL). Comprehensive lifestyle-modification might increase HrQoL and decrease disease activity. Ninety-seven patients in clinical remission with impaired HrQoL were randomly assigned to a 10 week comprehensive lifestyle-modification program (LSM; n = 47; 50.28 ± 11.90 years) or control (n = 50; 45.54 ± 12.49 years) that received a single workshop of intense training in naturopathic self-help strategies. Primary outcome was HrQoL (Inflammatory Bowel Disease Questionnaire; IBDQ) at week 12. Secondary outcomes included IBDQ subscales; generic HrQoL; disease activity and microbiome. Both groups showed improvement in HrQoL from baseline to post-treatment at week 12. The IBDQ sum score showed no significant group difference (p = 0.251). If patients attended more than 50% of the training sessions, a significant group effect (p = 0.034) was evident in favor of LSM. In addition, the SF-36 mental component summary (p = 0.002) was significantly different between the groups in favor of LSM. Disease activity microbiome and adverse events did not differ. Both a single workshop and a 10-week comprehensive lifestyle-modification program can improve HrQoL in patients with ulcerative colitis in remission with no apparent effects on clinical disease activity. A treatment difference was observed when examining a subsample of patients who attended ≥ 50% of sessions.This publication has 43 references indexed in Scilit:
- The SILVA ribosomal RNA gene database project: improved data processing and web-based toolsNucleic Acids Research, 2012
- Evaluation of general 16S ribosomal RNA gene PCR primers for classical and next-generation sequencing-based diversity studiesNucleic Acids Research, 2012
- Associating microbiome composition with environmental covariates using generalized UniFrac distancesBioinformatics, 2012
- Barcoded Primers Used in Multiplex Amplicon Pyrosequencing Bias AmplificationApplied and Environmental Microbiology, 2011
- UCHIME improves sensitivity and speed of chimera detectionBioinformatics, 2011
- Assessing health‐related quality of life in patients with inflammatory bowel disease in Zhejiang, ChinaJournal of Clinical Nursing, 2009
- Validierung der Deutschen Version (Kompetenznetz „Chronisch entzündliche Darmerkrankungen”) des Inflammatory Bowel Disease Questionnaire IBDQ-DPPmP - Psychotherapie · Psychosomatik · Medizinische Psychologie, 2006
- Effects of Mind-Body Therapy on Quality of Life and Neuroendocrine and Cellular Immune Functions in Patients with Ulcerative ColitisPsychotherapy and Psychosomatics, 2005
- Der deutsche SF-36 Health Survey Übersetzung und psychometrische Testung eines krankheitsübergreifenden Instruments zur Erfassung der gesundheitsbezogenen LebensqualitätJournal of Public Health, 1995
- The MOS 36-ltem Short-Form Health Survey (SF-36)Medical Care, 1992