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D1/5 dopamine receptors are necessary for learning a novel context

Fares Sayegh, Laurie Herraiz, Morgane Colom, Sébastien Lopez, , Lionel Dahan
Published: 16 May 2022

Abstract: Dopamine participates in encoding memories and could either encode rewarding/aversive value of unconditioned stimuli or act as a novelty signal triggering contextual learning. Here we show that intraperitoneal injection of the dopamine D1/5R antagonist SCH23390 impairs contextual fear conditioning and tone-shock association, while intrahippocampal injection only impairs contextual fear conditioning. By using the context pre-exposure facilitation effect test, we show that SCH23390 is able to block the encoding of the context during the pre-exposure phase. Thus, we provide additional evidence that dopamine is involved in encoding conjunctive representations of new contexts.
Keywords: dopamine / fear / SCH23390 / encoding / pre exposure / impairs contextual

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