Buffalo pox is a rare disorder associated with significant morbidity and mortality. There are only few published case reports. With the presence of few sporadic cases among milkers even today, the case presentation of buffalo pox infections since 2013-2014 is highly pertinent. A case series of individuals presenting with buffalo pox like lesions at different parts of the body with or without added symptoms of body ache, fever, myalgia, lymphadenopathy is presented. Here interesting is dermatologist {author} contracted the infection from patient. Due to the limitation of accessibility to differential diagnosis labs in rural India and due to the rare incidence of the disease, early recognition of signs and symptoms can prevent the spread of the disease. Sharing of specific experience of medical practitioner and timely interventions are crucial in preventing the spread of harmful zoonosis.