Short‐term caloric restriction induced bone loss in both axial and appendicular bones by increasing adiponectin
- 29 May 2020
- journal article
- research article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 1474 (1), 47-60
- https://doi.org/10.1111/nyas.14380
Abstract
Caloric restriction (CR) is well described and has received extensive attention for its multiple benefits, including longevity and stress resistance. However, some studies have shown that CR negatively influences bone, although a mechanism hasn't been provided. Adiponectin, an adipocyte‐derived hormone, can affect bone metabolism by various pathways. To explore the role of adiponectin in short‐term CR on bone, we tested the effect of short‐term CR on limb bones (tibia and femur) and lumbar vertebral bodies of young C57BL/6 wild‐type (WT) and adiponectin‐deficient (Apn –/–) mice. Two dietary regimes, ad libitum (AL) and CR (70% of the AL diet), were used. Dietary restriction led to increased serum adiponectin in WT mice, while bone mineral density, bone microarchitecture, and biomechanical outcomes of limb bone and vertebrae were decreased. In contrast, bone length, microarchitecture, and biomechanical outcomes were not impaired after CR in Apn –/– mice. Furthermore, CR increased adiponectin expression both in white adipose tissue and bone marrow adipose tissue in young WT mice. Histology analysis showed that expansion of bone marrow adipose tissue after CR in Apn –/– mice was impaired compared with WT mice. These results suggest that increased adiponectin induced by short‐term CR may negatively influence bones.Keywords
This publication has 39 references indexed in Scilit:
- Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cellsNature Medicine, 2012
- Changes in chemical composition of cortical bone associated with bone fragility in rat model with chronic kidney diseaseBone, 2011
- Serum IGF-1 Affects Skeletal Acquisition in a Temporal and Compartment-Specific MannerPLOS ONE, 2011
- Cardiovascular protection afforded by caloric restriction: Essential role of nitric oxide synthaseGeriatrics & Gerontology International, 2011
- Caloric restriction leads to high marrow adiposity and low bone mass in growing miceJournal of Bone and Mineral Research, 2010
- Extending Healthy Life Span—From Yeast to HumansScience, 2010
- Caloric Restriction Decreases Cortical Bone Mass but Spares Trabecular Bone in the Mouse Skeleton: Implications for the Regulation of Bone Mass by Body WeightJournal of Bone and Mineral Research, 2008
- Cardioprotective Effects of Short-Term Caloric Restriction Are Mediated by Adiponectin via Activation of AMP-Activated Protein KinaseCirculation, 2007
- Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndromeJCI Insight, 2006
- Increased β-Oxidation but No Insulin Resistance or Glucose Intolerance in Mice Lacking AdiponectinOnline Journal of Public Health Informatics, 2002