Is There a Role for the Microbiome and Sudden Death? A Systematic Review
Open Access
- 4 December 2021
- Vol. 11 (12), 1345
- https://doi.org/10.3390/life11121345
Abstract
Background. Sudden unexpected death (SUD) is one of the most important and worthy investigation case profiles in emergency medicine and forensic pathology. Sudden unexpected deaths in adults (SUDA) are frequently caused by cardiac events, while infections usually cause those in infants younger than one year (SUDI), and to a lesser extent, in children older than one year (SUDC). However, in some instances of children under the age of one dying (SIDS), a cause is not discovered despite a thorough investigation that includes a review of clinical history, examination of the death scene, and a complete autopsy. Several studies demonstrate that the microbiome influences host immunity, alters susceptibility to viral respiratory infections, and has a vital role in various health, disease, and death outcomes. The main objective of this systematic review was to compile and offer a complete vision of the main lines of research on microbiome and sudden death that have emerged in recent years and their relationship with forensic sciences, as well as the possible contributions or limitations in the field of forensic sciences. Methods. Following PRISMA principles, a systematic evaluation of the microbiome and sudden death in forensic science was conducted. In this review, our study classified the sudden deaths as SUDA, SUDI, and SIDS. Results. The role of microbiome research in sudden death is discussed in this review. Various studies have linked the detection of different bacteria or viruses as a probable cause of sudden death. Bacteria analysed differ between studies that used autopsy specimens from deaths classified as SUDA, SUDI, and SIDS, or, except in the case of Staphylococcus aureus and Escherichia coli, which have been analysed in both SUDI and SIDS autopsies. In the case of viruses, only Cytomegalovirus has been analysed in both SIDS and SUDI cases. However, all the viruses studied are respiratory viruses found in samples of nasopharyngeal or lung fluid. Conclusions. Although the application of the microbiome in sudden death and other fields of forensic science is still in its early stages, a role of the microbiome in sudden deaths cannot be ruled out, but we cannot conclude that it is a significant factor either.Keywords
This publication has 78 references indexed in Scilit:
- Populations of a cyprinid fish are self-sustaining despite widespread feminization of malesBMC Biology, 2014
- Epidemiología de la muerte súbita cardiacaRevista Española de Cardiología Suplementos, 2013
- Near-Universal Prevalence of Pneumocystis and Associated Increase in Mucus in the Lungs of Infants With Sudden Unexpected DeathClinical Infectious Diseases, 2012
- Postnatal parental smoking: an important risk factor for SIDSEuropean Journal of Pediatrics, 2011
- Microbiota regulates immune defense against respiratory tract influenza A virus infectionProceedings of the National Academy of Sciences of the United States of America, 2011
- Qualitative Analysis of Beliefs and Perceptions about Sudden Infant Death Syndrome in African-American Mothers: Implications for Safe Sleep RecommendationsThe Journal of Pediatrics, 2010
- Sudden Death in Pediatric PopulationsKorean Circulation Journal, 2010
- Microbial Prevalence, Diversity and Abundance in Amniotic Fluid During Preterm Labor: A Molecular and Culture-Based InvestigationPLOS ONE, 2008
- Inflammatory responses in sudden infant death syndrome – past and present viewsFEMS Immunology & Medical Microbiology, 1999
- Inflammatory responses in sudden infant death syndrome – past and present viewsFEMS Immunology & Medical Microbiology, 1999