The Golgi: Keeping It Unapologetically Basic
- 1 June 2020
- journal article
- editorial
- Published by American Association for Cancer Research (AACR) in Cancer Discovery
- Vol. 10 (6), 768-770
- https://doi.org/10.1158/2159-8290.cd-20-0357
Abstract
Summary: Tumor cells maintain a reverse pH gradient relative to normal cells, conferring cell-intrinsic and cell-extrinsic benefits that sustain tumor growth. In this issue of Cancer Discovery, Galenkamp and colleagues reveal that NHE7 mediates acidification of the trans-Golgi network in pancreatic ductal adenocarcinoma, which is critical for the maintenance of cytosolic pH and consequently tumor growth. See related article by Galenkamp et al., p. 822.Keywords
This publication has 10 references indexed in Scilit:
- Golgi Acidification by NHE7 Regulates Cytosolic pH Homeostasis in Pancreatic Cancer CellsCancer Discovery, 2020
- STAT3 associates with vacuolar H+-ATPase and regulates cytosolic and lysosomal pHCell Research, 2018
- Tumour acidosis: from the passenger to the driver's seatNature Reviews Cancer, 2017
- Roles of pH and the Na + /H + exchanger NHE1 in cancer: From cell biology and animal models to an emerging translational perspective?Seminars in Cancer Biology, 2016
- Genetics and biology of pancreatic ductal adenocarcinomaGenes & Development, 2016
- Activity of the Monocarboxylate Transporter 1 Inhibitor AZD3965 in Small Cell Lung CancerClinical Cancer Research, 2014
- Actin filament severing by cofilin is more important for assembly than constriction of the cytokinetic contractile ringThe Journal of cell biology, 2011
- Dysregulated pH: a perfect storm for cancer progressionNature Reviews Cancer, 2011
- New insights into the physiological role of carbonic anhydrase IX in tumour pH regulationOncogene, 2010
- A Membrane-Proximal Region in the C-Terminal Tail of NHE7 Is Required for Its Distribution in the Trans-Golgi Network, Distinct from NHE6 Localization at EndosomesThe Journal of Membrane Biology, 2010