INSM1 Is a Highly Specific Marker of Neuroendocrine Differentiation in Primary Neoplasms of the Gastrointestinal Tract, Appendix, and Pancreas
- 3 March 2020
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Clinical Pathology
- Vol. 153 (6), 811-820
- https://doi.org/10.1093/ajcp/aqaa014
Abstract
Objectives INSM1 has been described as a sensitive and specific neuroendocrine marker. This study aims to compare INSM1 with traditional neuroendocrine markers in gastrointestinal neuroendocrine neoplasms. Methods Retrospective review (2008-2018) was used to retrieve paraffin-embedded tissue from 110 gastrointestinal neuroendocrine neoplasms and controls that was subsequently stained with INSM1, synaptophysin, chromogranin, CD56, and Ki-67. Results INSM1 was positive in 16 of 17 (94.1%) gastric, 17 of 18 (94.4%) pancreatic, 13 of 18 (72.2%) small bowel, 17 of 21 (81.0%) colonic, and 26 of 36 (72.2%) appendiceal tumors. INSM1 was positive in 58 of 70 (82.9%) well-differentiated neuroendocrine tumors, 17 of 20 (85.0%) poorly differentiated neuroendocrine carcinomas, 8 of 11 (72.7%) low-grade goblet cell adenocarcinomas (grade 1), and 6 of 9 (66.7%) high-grade goblet cell adenocarcinomas (grade 2/3). INSM1 sensitivity for neuroendocrine neoplasms (80.9%) was less than that of synaptophysin (99.1%), chromogranin (88%), and CD56 (95.3%); specificity was higher (95.7% vs 86.0%, 87.3%, and 86.0%, respectively). Conclusions INSM1 is a useful marker of neuroendocrine differentiation in gastrointestinal neuroendocrine and mixed neuroendocrine neoplasms. Compared with traditional neuroendocrine markers, INSM1 is less sensitive but more specific.Keywords
This publication has 21 references indexed in Scilit:
- INSM1 is a Sensitive and Specific Marker of Neuroendocrine Differentiation in Head and Neck TumorsThe American Journal of Surgical Pathology, 2018
- INSM1 expression and its diagnostic significance in extraskeletal myxoid chondrosarcomaLaboratory Investigation, 2018
- Insulinoma-associated protein 1 (INSM1) is a useful marker for pancreatic neuroendocrine tumorMedical Molecular Morphology, 2018
- Insulinoma‐associated protein 1 is a sensitive and specific marker of neuroendocrine lung neoplasms in cytology specimensCancer Cytopathology, 2018
- Insulinoma‐associated 1: A novel nuclear marker in Merkel cell carcinoma (cutaneous neuroendocrine carcinoma)Journal of Cutaneous Pathology, 2017
- INSM1 Demonstrates Superior Performance to the Individual and Combined Use of Synaptophysin, Chromogranin and CD56 for Diagnosing Neuroendocrine Tumors of the Thoracic CavityThe American Journal of Surgical Pathology, 2017
- A new marker, insulinoma-associated protein 1 (INSM1), for high-grade neuroendocrine carcinoma of the uterine cervix: Analysis of 37 casesGynecologic Oncology, 2016
- INSM1: A Novel Immunohistochemical and Molecular Marker for Neuroendocrine and Neuroepithelial NeoplasmsAmerican Journal of Clinical Pathology, 2015
- Structure, expression, and biological function of INSM1 transcription factor in neuroendocrine differentiationThe FASEB Journal, 2009
- The Zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic β cells and intestinal endocrine cellsGenes & Development, 2006