The effects of intra-ovarian autologous platelet rich plasma injection on IVF outcomes of poor responder women and women with premature ovarian insufficiency
Open Access
- 8 March 2022
- journal article
- research article
- Published by Galenos Yayinevi in Journal of the Turkish-German Gynecological Association
- Vol. 23 (1), 14-21
- https://doi.org/10.4274/jtgga.galenos.2021.2021.0134
Abstract
Objective: There are controversial results regarding the administrations of platelet rich plasma (PRP) to increase in-vitro fertilization (IVF) success rates in the current literature. The aim of this study was to evaluate the effects of intra-ovarian PRP injections on IVF outcomes of poor responder women and women with premature ovarian insufficiency (POI). Material and Methods: The medical history and outcome of women receiving intra-ovarian PRP injections performed in a single tertiary center between 2018 and 2021 was retrospectively reviewed. Results: In total 71 women were included, of whom 21 were diagnosed with POI according to European Society of Human Reproduction and Embryology criteria and 50 were poor responders according to Bologna criteria. Number of retrieved oocytes, number of 2 pronuclear embryos and number of cleavage stage embryos were significantly higher in poor responder women after PRP injections. However clinical pregnancy rates and live birth delivery rates were similar before and after PRP injections in poor responders. In women with POI, 8 embryos were obtained in cycles commenced after PRP injections but no clinical pregnancies were achieved in this group of patients. Conclusion: Intra-ovarian PRP injections do not appear to increase live birth rates or clinical pregnancy rates in poor responder women or in those with POI, in this cohort.Keywords
This publication has 44 references indexed in Scilit:
- The Anti-inflammatory and Matrix Restorative Mechanisms of Platelet-Rich Plasma in OsteoarthritisThe American Journal of Sports Medicine, 2013
- Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatmentProceedings of the National Academy of Sciences of the United States of America, 2013
- Growth differentiation factor 9:bone morphogenetic protein 15 heterodimers are potent regulators of ovarian functionsProceedings of the National Academy of Sciences of the United States of America, 2013
- The Istanbul consensus workshop on embryo assessment: proceedings of an expert meetingHuman Reproduction, 2011
- Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF)Trends in Biotechnology, 2009
- Redundant Roles of SMAD2 and SMAD3 in Ovarian Granulosa Cells In VivoMolecular and Cellular Biology, 2008
- Premature Luteinization and Cumulus Cell Defects in Ovarian-SpecificSmad4Knockout MiceMolecular Endocrinology, 2006
- Effect of platelet concentration in platelet-rich plasma on peri-implant bone regenerationBone, 2004
- Bone growth factors in maxillofacial skeletal reconstructionInternational Journal of Oral & Maxillofacial Surgery, 2002
- In VivoTreatment with GDF-9 Stimulates Primordial and Primary Follicle Progression and Theca Cell Marker CYP17 in Ovaries of Immature Rats1Endocrinology, 2000