Predictive Value of Delphian Lymph Node Metastasis in the Thyroid Cancer
- 25 January 2021
- journal article
- research article
- Published by Wiley in The Laryngoscope
- Vol. 131 (9), 1990-1996
- https://doi.org/10.1002/lary.29426
Abstract
Objective/Hypothesis To evaluate the diagnostic accuracy of Delphian lymph node (DLN) metastasis for the prediction of central lymph node (CLN) metastasis and lateral lymph node (LLN) metastasis. Methods Two authors independently reviewed the six databases (Cochrane database, Embase, Google Scholar, PubMed, SCOPUS, and Web of Science). Four parameters were extracted from each study: true positive, true negative, false positive, and false negative. The quality of the methodology was evaluated using the Quality Assessment of Diagnostic Accuracy Studies ver. 2 tool. Results The diagnostic odds ratio of DLN in CLN metastasis was 8.859 (95% confidence interval [CI], 4.419; 16.578). The area under the summary receiver operating characteristic curve was 0.748. The diagnostic odds ratio of DLN in LLN metastasis was 7.61 (95% CI, 4.48; 12.94). The area under the summary receiver operating characteristic curve was 0.837. DLN metastasis was moderately predictive of CLN metastasis (sensitivity = 32%, specificity = 95%), LLN metastasis (sensitivity = 52%, specificity = 89%), and contralateral CLN metastasis (sensitivity = 46%, specificity = 85%). DLN metastasis had statistically significant correlation with specific clinicopathological characteristics, including younger age (< 45 years old), bilaterality, capsule invasion, extrathyroidal extension, lymphovascular invasion, male sex, multifocality, and tumor size (> 1 cm). Conclusions The higher specificities of DLN pathology may help predict central and lateral compartment involvement in patients with thyroid cancer. Level of Evidence N/A Laryngoscope, 2021Keywords
Funding Information
- National Research Foundation of Korea (2018M3A9E8020856, 2018R1D1A1B07045421, 2019M3A9H2032424, 2019M3E5D5064110, 2020R1I1A1A01051844)
This publication has 35 references indexed in Scilit:
- Predictive Factors for Different Subgroups of Central Lymph Node Metastasis in Unilateral Papillary Thyroid CarcinomaORL, 2013
- Experience and analysis of Delphian lymph node metastasis in patients with papillary thyroid carcinomaWorld Journal of Surgical Oncology, 2012
- Performing Contralateral Central Lymph Node Dissection in Papillary Thyroid Carcinoma: A Decision ApproachThyroid®, 2011
- Incidence and Significance of Delphian Node Metastasis in Papillary Thyroid CancerAnnals of Surgery, 2011
- Central Lymph Node Metastasis of Unilateral Papillary Thyroid Carcinoma: Patterns and Factors Predictive of Nodal Metastasis, Morbidity, and RecurrenceAnnals of Surgical Oncology, 2011
- Thyroid Cancer Gender DisparityFuture Oncology, 2010
- Efficacy of preoperative neck ultrasound in the detection of cervical lymph node metastasis from thyroid cancerThe Laryngoscope, 2010
- Predictive value of the Delphian and level VI nodes in papillary thyroid cancerAnz Journal of Surgery, 2010
- Delphian node metastasis in head and neck cancers—Oracle or myth?Journal of Surgical Oncology, 2010
- The Delphian Lymph Node in Thyroid CancerAnnals of Surgery, 2008