The Cancer Chemopreventive and Therapeutic Potential of Tetrahydrocurcumin
Open Access
- 29 May 2020
- journal article
- review article
- Published by MDPI AG in Biomolecules
- Vol. 10 (6), 831
- https://doi.org/10.3390/biom10060831
Abstract
In recent decades, cancer has been one of the leading causes of death worldwide. Despite advances in understanding the molecular basis of tumorigenesis, diagnosis, and clinical therapies, the discovery and development of effective drugs is an active and vital field in cancer research. Tetrahydrocurcumin is a major curcuminoid metabolite of curcumin, naturally occurring in turmeric. The interest in tetrahydrocurcumin research is increasing because it is superior to curcumin in its solubility in water, chemical stability, bioavailability, and anti-oxidative activity. Many in vitro and in vivo studies have revealed that tetrahydrocurcumin exerts anti-cancer effects through various mechanisms, including modulation of oxidative stress, xenobiotic detoxification, inflammation, proliferation, metastasis, programmed cell death, and immunity. Despite the pharmacological similarities between tetrahydrocurcumin and curcumin, the structure of tetrahydrocurcumin determines its distinct and specific molecular mechanism, thus making it a potential candidate for the prevention and treatment of cancers. However, the utility of tetrahydrocurcumin is yet to be evaluated as only limited pharmacokinetic and oral bioavailability studies have been performed. This review summarizes research on the anti-cancer properties of tetrahydrocurcumin and describes its mechanisms of action.Keywords
This publication has 111 references indexed in Scilit:
- Oxidative damage and carcinogenesisContemporary Oncology, 2012
- Discovery of curcumin, a component of golden spice, and its miraculous biological activitiesClinical and Experimental Pharmacology and Physiology, 2011
- Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganismProceedings of the National Academy of Sciences of the United States of America, 2011
- Hallmarks of Cancer: The Next GenerationCell, 2011
- Controlled Release of Oral Tetrahydrocurcumin from a Novel Self-Emulsifying Floating Drug Delivery System (SEFDDS)AAPS PharmSciTech, 2010
- A liquid chromatography–tandem mass spectrometric method for quantification of curcuminoids in cell medium and mouse plasmaJournal of Chromatography B, 2010
- Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instabilityCarcinogenesis: Integrative Cancer Research, 2009
- Dimethoxycurcumin, a Synthetic Curcumin Analogue, Induces Heme Oxygenase-1 Expression through Nrf2 Activation in RAW264.7 MacrophagesJournal of Clinical Biochemistry and Nutrition, 2009
- Curcumin Structure-Function, Bioavailability, and Efficacy in Models of Neuroinflammation and Alzheimer's DiseaseThe Journal of pharmacology and experimental therapeutics, 2008
- The Hallmarks of CancerCell, 2000