Factors Associated with Thyroid Disorders and Iodine Adequacy in Pregnant Saudi Women
- 25 July 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Biological Trace Element Research
- Vol. 199 (5), 1715-1728
- https://doi.org/10.1007/s12011-020-02301-w
Abstract
Little is known about iodine adequacy and gestational thyroid disorders (GTDs) in Saudi Arabia. This study measured the rates of GTDs and iodine adequacy in 810 healthy Saudi women. Concentrations of serum thyroid hormones and 24-h urine iodine (24-h UIC), and GTDs were diagnosed according to the American Thyroid Association guidelines. Dietary and socioeconomic data to determine factors associated with GTDs and iodine insufficiency were collected. GTDs were detected in 265 women (32.7%) as follows: subclinical (SCH; 20.2%) and overt (OH; 5.8%) hypothyroidism, isolated hypothyroxinemia (ISH; 4.7%) and hyperthyroidism (2%). The SCH (109.2 μg/L; IQR: 77.2–149.7), OH (95.3 μg/L; IQR: 74.3–130.5) and ISH (107.3 μg/L; IQR: 65.5–133.1) groups had median 24-h UIC below the WHO recommended limit, whereas the euthyroid (191.4 μg/L; IQR: 170.03–219.8) and hyperthyroid (159.5 μg/L; IQR: 152.9–238.3) groups were iodine sufficient. Numbers of pregnancies, less education, not consuming iodized salt and not using iodine supplements increased risk of hypothyroidism and ISH. Contrariwise, interval ≥ 3 years from last pregnancy and higher 24-h UIC decreased odds of hypothyroidism and ISH. Moreover, dairy products and egg consumption were markedly lower in all GTD groups. Dairy products and seafood consumption correlated independently with 24-h UIC of the study participants, whereas consuming yogurt, eggs, redfish and shellfish protected against GTDs. In conclusion, GTDs appear to be prevalent in pregnant Saudi women and the hypothyroid and hypothyroxinemia groups had iodine insufficiency. However, consuming iodized salt, iodine supplements, dairy products, seafoods and eggs may protect against GTDs.Funding Information
- Umm Al-Qura University (15-MED-3-1-0054)
This publication has 68 references indexed in Scilit:
- Comparison of Population Iodine Estimates from 24-Hour Urine and Timed-Spot Urine SamplesThyroid®, 2014
- Validation of a short food frequency questionnaire specific for iodine in UK females of childbearing ageJournal of Human Nutrition and Dietetics, 2014
- Effect of inadequate iodine status in UK pregnant women on cognitive outcomes in their children: results from the Avon Longitudinal Study of Parents and Children (ALSPAC)The Lancet, 2013
- Risk of Suboptimal Iodine Intake in Pregnant Norwegian WomenNutrients, 2013
- Iodine status of UK schoolgirls: a cross-sectional surveyThe Lancet, 2011
- Iodine sources and iodine levels in pregnant women from an area without known iodine deficiencyClinical Endocrinology, 2009
- Creatinine corrections for estimating children's and adult's pesticide intake doses in equilibrium with urinary pesticide and creatinine concentrationsJournal of Exposure Science & Environmental Epidemiology, 2007
- Thyroid function abnormalities and antithyroid antibody prevalence in pregnant women at high risk for gestational diabetes mellitusGynecological Endocrinology, 2006
- Iodine content of food groupsJournal of Food Composition and Analysis, 2005
- Parity as a Thyroid Size-Determining Factor in Areas with Moderate Iodine DeficiencyJournal of Clinical Endocrinology & Metabolism, 2000