The 2021 update of the EPA’s adverse outcome pathway database
Open Access
- 12 July 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Scientific Data
- Vol. 8 (1), 1-9
- https://doi.org/10.1038/s41597-021-00962-3
Abstract
The EPA developed the Adverse Outcome Pathway Database (AOP-DB) to better characterize adverse outcomes of toxicological interest that are relevant to human health and the environment. Here we present the most recent version of the EPA Adverse Outcome Pathway Database (AOP-DB), version 2. AOP-DB v.2 introduces several substantial updates, which include automated data pulls from the AOP-Wiki 2.0, the integration of tissue-gene network data, and human AOP-gene data by population, semantic mapping and SPARQL endpoint creation, in addition to the presentation of the first publicly available AOP-DB web user interface. Potential users of the data may investigate specific molecular targets of an AOP, the relation of those gene/protein targets to other AOPs, cross-species, pathway, or disease-AOP relationships, or frequencies of AOP-related functional variants in particular populations, for example. Version updates described herein help inform new testable hypotheses about the etiology and mechanisms underlying adverse outcomes of environmental and toxicological concern.Funding Information
- U.S. Environmental Protection Agency (n/a)
This publication has 31 references indexed in Scilit:
- A global reference for human genetic variationNature, 2015
- The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humansScience, 2015
- Understanding multicellular function and disease with human tissue-specific networksNature Genetics, 2015
- The Genotype-Tissue Expression (GTEx) projectNature Genetics, 2013
- An integrated map of genetic variation from 1,092 human genomesNature, 2012
- Update on EPA’s ToxCast Program: Providing High Throughput Decision Support Tools for Chemical Risk ManagementChemical Research in Toxicology, 2012
- ConsensusPathDB: toward a more complete picture of cell biologyNucleic Acids Research, 2010
- In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast ProjectEnvironmental Health Perspectives, 2010
- The NCBI BioSystems databaseNucleic Acids Research, 2009
- ConsensusPathDB—a database for integrating human functional interaction networksNucleic Acids Research, 2008