Atypical Sarcoidosis Diagnosed by Massive Splenomegaly
Open Access
- 1 January 2020
- journal article
- research article
- Published by Japanese Society of Internal Medicine in Internal Medicine
- Vol. 59 (5), 641-648
- https://doi.org/10.2169/internalmedicine.3646-19
Abstract
We examined a 22-year-old woman who was admitted to our hospital with abdominal distention. At 19 years of age, the patient presented with hepatosplenomegaly. She was examined several times in another hospital; however, the cause was unidentified. Our evaluation showed severe pancytopenia and a spleen 13x24 cm in size. The serum levels of angiotensin-converting enzyme and lysozyme were elevated. She was diagnosed with liver sarcoidosis based on non-caseating epithelioid granuloma in liver biopsy tissue. To improve the symptoms, splenectomy was performed, and her pancytopenia and symptoms improved. Sarcoidosis should be considered in cases of massive splenomegaly.This publication has 25 references indexed in Scilit:
- Granulomatous liver diseases: A reviewJournal of the Formosan Medical Association, 2012
- HLA-DQB1*0602 allele is associated with splenomegaly in Japanese sarcoidosisJournal of Internal Medicine, 2007
- Clinical manifestations of sarcoid liver diseaseJournal of Gastroenterology and Hepatology, 2004
- Hepatic SarcoidosisThe American Journal of Surgical Pathology, 1993
- Massive Splenomegaly in SarcoidosisSouthern Medical Journal, 1992
- Splenomegaly in SarcoidosisArchives of Internal Medicine, 1980
- Splenomegaly in sarcoidosisArchives of Internal Medicine, 1980
- Splenomegaly and splenectomy in sarcoidosis.Journal of Clinical Pathology, 1979
- SARCOIDOSIS AND CHRONIC HEPATIC DISEASEMedicine, 1970
- SARCOIDOSIS PRODUCING PORTAL HYPERTENSIONAnnals of Surgery, 1949