Crystal structure ofN-(tert-butoxycarbonyl)phenylalanyldehydroalanine isopropyl ester (Boc–Phe–ΔAla–OiPr)
Open Access
- 29 November 2014
- journal article
- research article
- Published by International Union of Crystallography (IUCr) in Acta Crystallographica Section E: Crystallographic Communications
- Vol. 70 (12), 599-602
- https://doi.org/10.1107/s1600536814025197
Abstract
In the title compound, the dehydrodipeptide (Boc-Phe- Delta Ala-OiPr, C20H28N2O5), the molecule has a trans conformation of the N-methylamide group. The geometry of the dehydroalanine moiety is to some extent different from those usually found in simple peptides, indicating conjugation between the H2C=C group and the peptide bond. The bond angles around dehydroalanine have unusually high values due to the steric hindrance, the same interaction influencing the slight distortion from planarity of the dehydroalanine. The molecule is stabilized by intramolecular interactions between the isopropyl group and the N atoms of the peptide main chain. In the crystal, an N-H center dot center dot center dot O hydrogen bond links the molecules into ribbons, giving a herringbone head-tohead packing arrangement extending along the [100] direction. In the stacks, the molecules are linked by weak C-H center dot center dot center dot O hydrogen-bonding associations.Keywords
This publication has 24 references indexed in Scilit:
- Use of intensity quotients and differences in absolute structure refinementActa crystallographica Section B, Structural science, crystal engineering and materials, 2013
- Influence of solvents on conformation of dehydropeptidesJournal of Molecular Structure, 2013
- Conformations of peptides containing a chiral cyclic α, α‐disubstituted α‐amino acid within the sequence of Aib residuesJournal of Peptide Science, 2010
- Controlling the helical screw sense of peptides with C -terminal L-valineJournal of Peptide Science, 2010
- Methyl Mercapturate Synthesis: An Efficient, Convenient and Simple MethodMolecules, 2008
- Pentapeptides containing two dehydrophenylalanine residues - synthesis, structural studies and evaluation of their activity towards cathepsin CJournal of Peptide Science, 2008
- A short history of SHELXActa Crystallographica Section A Foundations of Crystallography, 2007
- Lantibiotics: Peptides of Diverse Structure and FunctionAnnual Review of Microbiology, 2007
- Synthesis of Tetrapeptidep-nitrophenylanilides containing dehydroalanine and dehydrophenylalanine and their influence on cathepsin C activityJournal of Peptide Science, 2001
- The enzyme stability of dehydropeptidesBiochemical and Biophysical Research Communications, 1978