Screen-detected gallstone disease and risk of liver and pancreatic cancer: The Kailuan Cohort Study
- 1 July 2020
- journal article
- research article
- Published by Wiley in Liver International
- Vol. 40 (7), 1744-1755
- https://doi.org/10.1111/liv.14456
Abstract
Background Few studies have examined the risk of gastrointestinal cancers in screen-detected gallstone disease. This study aimed to investigate the association between screen-detected gallstone disease and gastrointestinal cancers using the Kailuan cohort, a population-based prospective cohort initiated in 2006. Methods A total of 79 809 men who underwent gallbladder ultrasonography, were free of cancers in 2006 and did not have gastrointestinal cancers within one year were enrolled. A Cox proportional hazards model with age as the timescale was used to evaluate the association between screen-detected gallstone disease and gastrointestinal cancers. Results We identified 1264 cases with gastrointestinal cancers, including 303 cases with liver cancer and 94 cases with pancreatic cancer. Screen-detected gallstone disease increased the risk of liver cancer, with an HR of 2.28 [95% confidence interval (CI): 1.20-4.33, P = .012]. The association was modified by the hepatitis B surface antigen status. A non-significant positive association was observed between pancreatic cancer and gallstone disease (HR 2.19, 95% CI: 0.95-5.05, P = .065). However, the HR became significant after those individuals with diabetes were excluded (HR 2.60, 95% CI: 1.12-6.01, P = .026). Conclusion Screen-detected gallstone disease may predict the risk for liver and pancreatic cancer.Funding Information
- Special Fund of Chinese Central Government for Basic Scientific Research Operations in Commonweal Research Institutes (2017PT63001)
- CAMS Innovation Fund for Medical Sciences (2016-I2M-3-001)
This publication has 45 references indexed in Scilit:
- Inflammation and gastrointestinal cancer: An overviewCancer Letters, 2014
- Measures of Adiposity and Risk of Stroke in China: A Result from the Kailuan StudyPLOS ONE, 2013
- Postprandial gut hormone responses and glucose metabolism in cholecystectomized patientsAmerican Journal of Physiology-Gastrointestinal and Liver Physiology, 2013
- Prevalence of Ideal Cardiovascular Health and Its Relationship With the 4-Year Cardiovascular Events in a Northern Chinese Industrial CityCirculation: Cardiovascular Quality and Outcomes, 2012
- Role of endogenous cholecystokinin on growth of human pancreatic cancerInternational Journal of Oncology, 2011
- Gallstone Disease Is Associated With Increased Mortality in the United StatesGastroenterology, 2011
- Immunity, Inflammation, and CancerCell, 2010
- Risk of colorectal cancer and other cancers in patients with gall stones.Gut, 1996
- Pathogenesis and Treatment of GallstonesThe New England Journal of Medicine, 1993
- Ultrasound scanning in the detection of hepatic fibrosis and steatosis.BMJ, 1986