The Vitamin A and D Exposure of Cells Affects the Intracellular Uptake of Aluminum Nanomaterials and Its Agglomeration Behavior: A Chemo-Analytic Investigation
Open Access
- 14 February 2020
- journal article
- research article
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 21 (4), 1278
- https://doi.org/10.3390/ijms21041278
Abstract
Aluminum (Al) is extensively used for the production of different consumer products, agents, as well as pharmaceuticals. Studies that demonstrate neurotoxicity and a possible link to Alzheimer’s disease trigger concern about potential health risks due to high Al intake. Al in cosmetic products raises the question whether a possible interaction between Al and retinol (vitamin A) and cholecalciferol (vitamin D3) metabolism might exist. Understanding the uptake mechanisms of ionic or elemental Al and Al nanomaterials (Al NMs) in combination with bioactive substances are important for the assessment of possible health risk associated. Therefore, we studied the uptake and distribution of Al oxide (Al2O3) and metallic Al0 NMs in the human keratinocyte cell line HaCaT. Possible alterations of the metabolic pattern upon application of the two Al species together with vitamin A or D3 were investigated. Time-of-flight secondary ion mass spectrometry (ToF-SIMS) imaging and inductively coupled plasma mass spectrometry (ICP-MS) were applied to quantify the cellular uptake of Al NMs.This publication has 34 references indexed in Scilit:
- Application of Laser Postionization Secondary Neutral Mass Spectrometry/Time-of-Flight Secondary Ion Mass Spectrometry in Nanotoxicology: Visualization of Nanosilver in Human Macrophages and Cellular ResponsesACS Nano, 2011
- Dihydrosphingomyelin Impairs HIV-1 Infection by Rigidifying Liquid-Ordered Membrane DomainsCell Chemical Biology, 2010
- Molecular Surface Mass Spectrometry by SIMSPublished by Wiley ,2009
- The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitisCell Metabolism, 2006
- Dihydroceramide hinders ceramide channel formation: Implications on apoptosisApoptosis, 2006
- Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine ParticlesEnvironmental Health Perspectives, 2005
- Application of TOF-SIMS with Chemometrics To Discriminate between Four Different Yeast Strains from the Species Candida glabrata and Saccharomyces cerevisiaeAnalytical Chemistry, 2005
- Vitamin A Antagonizes Decreased Cell Growth and Elevated Collagen-Degrading Matrix Metalloproteinases and Stimulates Collagen Accumulation in Naturally Aged Human Skin1Journal of Investigative Dermatology, 2000
- Changes of epidermal cell morphology and keratin expression induced by inhibitors of protein kinase CJournal of Dermatological Science, 1992
- Activation of protein kinase C by phosphatidylinositol 4,5-bisphosphate: Possible involvement inBiochemical and Biophysical Research Communications, 1991