Risk factors and treatment outcomes of peristomal pyoderma gangrenosum in patients with inflammatory bowel disease
Open Access
- 1 June 2020
- journal article
- research article
- Published by Wiley in Alimentary Pharmacology & Therapeutics
- Vol. 51 (12), 1365-1372
- https://doi.org/10.1111/apt.15766
Abstract
Background Insufficient data exist for peristomal pyoderma gangrenosum (PPG), which primarily affects patients with inflammatory bowel disease (IBD). Aims To evaluate the risk factors and treatment response of PPG in IBD patients in a real-life cohort. Methods Cases of PPG were identified retrospectively using ICD-9/10 codes in patients with IBD who had an ostomy at a tertiary care centre. Disease-specific characteristics were compared between groups with and without PPG, and response to therapy was evaluated in patients with PPG. Results The cohort included 41 IBD patients with PPG and 123 IBD controls with an ostomy who never developed PPG. Patients with PPG were more likely to be female (76% vs 51%, P = 0.006), had higher BMIs (29.78 +/- 0.89 vs 23.53 +/- 0.51, P < 0.0001) and had increased usage of pouch belts (97% vs 71%, P = 0.0008) compared to controls. There were no differences in age at surgery (41.76 +/- 2.60 vs 43.49 +/- 1.50, P = 0.57) or IBD diagnosis (63% vs 54% Crohn's disease, P = 0.28) between PPG and controls. 85% of PPG patients achieved complete resolution with different treatments, including surgery. Complete resolution with topical corticosteroids and calcineurin inhibitors alone were low (14% and 13% respectively). Higher rates of complete resolution were reported with anti-tumour necrosis factor (TNF) agents (63%) and surgical interventions (80%). Conclusions Female gender, higher BMI and pouch belts were associated with increased risk of developing PPG. Most PPG cases resolved after treatment with the highest rates of complete resolution seen with anti-TNF agents and surgical intervention.This publication has 19 references indexed in Scilit:
- Diagnosis and management of peristomal pyoderma gangrenosum: A systematic reviewJournal of the American Academy of Dermatology, 2018
- Clinical features, causes, treatments, and outcomes of peristomal pyoderma gangrenosum (PPG) in 44 patients: The Mayo Clinic experience, 1996 through 2013Journal of the American Academy of Dermatology, 2016
- Risk factors for peristomal pyoderma gangrenosum complicating inflammatory bowel diseaseJournal of Crohn's and Colitis, 2013
- Pyoderma Gangrenosum: The Great Pretender and a Challenging DiagnosisJournal of Cutaneous Medicine and Surgery, 2011
- Pyoderma gangrenosum: an updated reviewJournal of the European Academy of Dermatology and Venereology, 2009
- Significance of Erythema Nodosum and Pyoderma Gangrenosum in Inflammatory Bowel DiseasesMedicine, 2008
- Diagnosis and treatment of pyoderma gangrenosumBMJ, 2006
- Clinical Features and Treatment of Peristomal Pyoderma GangrenosumJama-Journal Of The American Medical Association, 2000
- Twenty Cases of Peristomal Pyoderma GangrenosumArchives of Surgery, 2000
- Pyoderma gangrenosumThe Lancet, 1998