In-vivo impact of common cosmetic preservative systems in full formulation on the skin microbiome
Open Access
- 7 July 2021
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 16 (7), e0254172
- https://doi.org/10.1371/journal.pone.0254172
Abstract
Preservatives play an essentially role in ensuring that cosmetic formulations remain safe for use via control of microbial contamination. Commonly used preservatives include organic acids, alcohols and phenols and these play an essential role in controlling the growth of bacteria, fungi and moulds in substrates that can potentially act as a rich food source for microbial contaminants. Whilst the activity of these compounds is clear, both in vitro and in formulation, little information exists on the potential impact that common preservative systems, in full formulation, have on the skin’s resident microbiome. Dysbiosis of the skin’s microbiome has been associated with a number of cosmetic conditions but there currently are no in vivo studies investigating the potential for preservative ingredients, when included in personal care formulations under normal use conditions, to impact the cutaneous microbiome. Here we present an analysis of four in vivo studies that examine the impact of different preservation systems in full formulation, in different products formats, with varying durations of application. This work demonstrates that despite the antimicrobial efficacy of the preservatives in vitro, the skin microbiome is not impacted by preservative containing products in vivo.Keywords
This publication has 48 references indexed in Scilit:
- Propionibacterium acnes Strain Populations in the Human Skin Microbiome Associated with AcneJournal of Investigative Dermatology, 2013
- The skin microbiomeNature Reviews Microbiology, 2011
- Low‐level efficacy of cosmetic preservativesInternational Journal of Cosmetic Science, 2011
- Staphylococcus epidermidis Esp inhibits Staphylococcus aureus biofilm formation and nasal colonizationNature, 2010
- Staphylococcus epidermidis Antimicrobial δ-Toxin (Phenol-Soluble Modulin-γ) Cooperates with Host Antimicrobial Peptides to Kill Group A StreptococcusPLOS ONE, 2010
- The Human Oral Microbiome Database: a web accessible resource for investigating oral microbe taxonomic and genomic informationDatabase: The Journal of Biological Databases and Curation, 2010
- Contamination versus preservation of cosmetics: a review on legislation, usage, infections, and contact allergyContact Dermatitis, 2009
- UniFrac: a New Phylogenetic Method for Comparing Microbial CommunitiesApplied and Environmental Microbiology, 2005
- Palmitoleic Acid Isomer (C16:1Δ6) in Human Skin Sebum Is Effective against Gram-Positive BacteriaSkin Pharmacology and Physiology, 2003
- A New Method for the Quantitative Investigation of Cutaneous Bacteria*Journal of Investigative Dermatology, 1965