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Pyridazine and its related compounds: Part 38. Pyrimido[1,2-b]pyridazinone, synthesis and some reactions

Ali Abdel Hamid Deeb, Fatma Abdel Rahman El-Mariah, Heba Kamal Abd El-Mawgoud
European Journal of Chemistry , Volume 6; doi:10.5155/eurjchem.6.2.204-210.1252

Abstract: A new method of generating the fused heterocyclic system with bridge head nitrogen pyrimido[1,2-b]pyridazinone, from 3-amino-4,5,6-triphenylpyridazine and malonic acid in presence of phosphoryl chloride is described. The structures of the synthesized compounds were confirmed by their infrared, mass spectrum, 1H NMR and elemental analyses. The antimicrobial activity of the compounds obtained was examined against some selected microorganisms.
Keywords: nitrogen / antimicrobial / microorganisms / Structures / pyridazinone / compounds / phosphoryl / Pyrimido / Malonic / Triphenylpyridazine

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