Metal- and metal/oxide-based engineered nanoparticles and nanostructures: a review on the applications, nanotoxicological effects, and risk control strategies
- 27 February 2021
- journal article
- review article
- Published by Springer Science and Business Media LLC in Environmental Science and Pollution Research
- Vol. 28 (14), 16962-16981
- https://doi.org/10.1007/s11356-021-12996-6
Abstract
The production and demand of nanoparticles in the manufacturing sector and personal care products, release a large number of engineered nanoparticles (ENPs) into the atmosphere, aquatic ecosystems, and terrestrial environments. The intentional or involuntary incorporation of ENPs into the environment is carried out through different processes. The ENPs are combined with other compounds and release into the atmosphere, settling on the ground due to the water cycle or other atmospheric phenomena. In the case of aquatic ecosystems, the ENPs undergo hetero-aggregation and sedimentation, reaching different living organisms and flora, as well as groundwater. Accordingly, the high mobility of ENPs in diverse ecosystems is strongly related to physical, chemical, and biological processes. Recent studies have been focused on the toxicological effects of a wide variety of ENPs using different validated biological models. This literature review emphasizes the study of toxicological effects related to using the most common ENPs, specifically metal and metal/oxides-based nanoparticles, addressing different synthesis methodologies, applications, and toxicological evaluations. The results suggest negative impacts on biological models, such as oxidative stress, metabolic and locomotive toxicity, DNA replication dysfunction, and bioaccumulation. Finally, it was consulted the protocols for the control of risks, following the assessment and management process, as well as the classification system for technological alternatives and risk management measures of ENPs, which are useful for the transfer of technology and nanoparticles commercialization.Keywords
This publication has 208 references indexed in Scilit:
- Antibacterial properties of F-doped ZnO visible light photocatalystJournal of Hazardous Materials, 2017
- Emerging aspects of nanotoxicology in health and disease: From agriculture and food sector to cancer therapeuticsFood and Chemical Toxicology, 2016
- Silver nanoparticle films for metal enhanced luminescence: Toward development of plasmonic radiation detectors for medical applicationsSensors and Actuators B: Chemical, 2016
- Microglial cells (BV-2) internalize titanium dioxide (TiO2) nanoparticles: toxicity and cellular responsesEnvironmental Science and Pollution Research, 2016
- Emerging systems biology approaches in nanotoxicology: Towards a mechanism-based understanding of nanomaterial hazard and riskToxicology and Applied Pharmacology, 2015
- Noble metal nanoparticles embedding into polymeric materials: From fundamentals to applicationsAdvances in Colloid and Interface Science, 2015
- In vivo delivery, pharmacokinetics, biodistribution and toxicity of iron oxide nanoparticlesChemical Society Reviews, 2015
- Phytofabrication of bioinspired zinc oxide nanocrystals for biomedical applicationArtificial Cells, Nanomedicine, and Biotechnology, 2015
- Fate of engineered nanoparticles: Implications in the environmentCoordination Chemistry Reviews, 2015
- Synthesis and characterization of superparamagnetic iron oxide nanoparticles for biomedical applicationsHyperfine Interactions, 2009