Conductive collagen/polypyrrole-b-polycaprolactone hydrogel for bioprinting of neural tissue constructs
Open Access
- 1 January 1970
- journal article
- research article
- Published by AccScience Publishing in International Journal of Bioprinting
- Vol. 5 (1), 31-43
- https://doi.org/10.18063/ijb.v5i2.1.229
Abstract
Bioprinting is increasingly being used for fabrication of engineered tissues for regenerative medicine, drug testing, and other biomedical applications. The success of this technology lies with the development of suitable bioinks and hydrogels that are specific to the intended tissue application. For applications such as neural tissue engineering. conductivity plays an important role in determining the neural differentiation and neural tissue regeneration. Although several conductive hydrogels based on metal nanoparticles (NPs) such as gold and silver, carbon-based materials such as graphene and carbon nanotubes and conducting polymers such as polypyrrole (PPy) and polyanilinc were used, they possess several disadvantages. The long-term cytotoxicity of metal nanoparticles (NPs) and carbon-based materials restricts their use in regenerative medicine. The conductive polymers, on the other hand, are non-biodegradable and possess weak mechanical properties limiting their printability into three-dimensional constructs. The aim of this study is to develop a biodegradable. conductive, and printable hydrogel based on collagen and a block copolymer of PPy and polycaprolactone (PCL) (PPy-block-poly(caprolactone) [PPyb-PCLI) for bioprinting of neural tissue constructs. The printability, including the influence of the printing speed and material flow rate on the printed fiber width: theological properties: and cytotoxicity of these hydrogels were studied. The results prove that the collagen/PPy-b-PCL hydrogels possessed better printability and biocompatibility. Thus, the collagen/PPy-b-PCL hydrogels reported this study has the potential to be used in the bioprinting of neural tissue constructs for the repair of damaged neural tissues and drug testing or precision medicine applications.Keywords
This publication has 26 references indexed in Scilit:
- Reduced Graphene Oxide‐GelMA Hybrid Hydrogels as Scaffolds for Cardiac Tissue EngineeringSmall, 2016
- Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel BioinkJournal of Visualized Experiments, 2016
- An Injectable Self‐Assembling Collagen–Gold Hybrid Hydrogel for Combinatorial Antitumor Photothermal/Photodynamic TherapyAdvanced Materials, 2016
- In Situ Synthesis of Robust Conductive Cellulose/Polypyrrole Composite Aerogels and Their Potential Application in Nerve RegenerationAngewandte Chemie, 2014
- Genotoxicity and molecular response of silver nanoparticle (NP)-based hydrogelJournal of Nanobiotechnology, 2012
- Origin of Enhanced Stem Cell Growth and Differentiation on Graphene and Graphene OxideACS Nano, 2011
- Clusters of Superparamagnetic Iron Oxide Nanoparticles Encapsulated in a Hydrogel: A Particle Architecture Generating a Synergistic Enhancement of the T2 RelaxationACS Nano, 2011
- Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin SignalingCell, 2009
- Matrix Elasticity Directs Stem Cell Lineage SpecificationCell, 2006
- Overexpression of Lysyl Oxidase to Increase Matrix Crosslinking and Improve Tissue Strength in Dermal Wound HealingAnnals of Biomedical Engineering, 2006