Application and Prospect between m6A and LncRNA in Pancreatic Cancer
- 1 January 2023
- journal article
- Published by Hans Publishers in Advances in Clinical Medicine
- Vol. 13 (03), 3883-3888
- https://doi.org/10.12677/acm.2023.133556
Abstract
Pancreatic cancer is an aggressive and lethal malignancy among GI tract tumors with poor prog-nosis. m6A is the most common post-transcriptional modification and plays a crucial role in RNA output, translation, stabilization, maturation and decay. lncRNA is a class of molecules with tran-scriptional length over 200 nt, which normally do not participate in protein coding process directly, but in the form of RNA in protein coding gene regulation. Studies on the correlation between m6A modifications and lncRNAs are also underway. This paper presents a review of the latest research progress between m6A and lncRNA in PAAD, aiming to discuss the latest research and progress between m6A and LncRNA in pancreatic cancer.Keywords
This publication has 47 references indexed in Scilit:
- Non-coding RNAs as regulators in epigeneticsOncology Reports, 2016
- Post-transcriptional gene regulation by mRNA modificationsNature Reviews Molecular Cell Biology, 2016
- Identification of Spen as a Crucial Factor for Xist Function through Forward Genetic Screening in Haploid Embryonic Stem CellsCell Reports, 2015
- Systematic Discovery of Xist RNA Binding ProteinsCell, 2015
- Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012International Journal of Cancer, 2014
- Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferaseCell Research, 2014
- Long non-coding RNAs: new players in cell differentiation and developmentNature Reviews Genetics, 2013
- ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse FertilityMolecular Cell, 2013
- N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTONature Chemical Biology, 2011
- Long Noncoding RNA as Modular Scaffold of Histone Modification ComplexesScience, 2010