Ultra-small natural product based coordination polymer nanodots for acute kidney injury relief
- 3 February 2021
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Mater. Horiz.
- Vol. 8 (4), 1314-1322
- https://doi.org/10.1039/d0mh00193g
Abstract
Acute kidney injury (AKI) is frequently associated with reactive oxygen species (ROS) and causes high mortality in clinics annually, and nanotechnology-mediated antioxidative therapy is emerging as a novel strategy for AKI treatment. Herein, four kinds of natural antioxidants are able to coordinate with iron (Fe) ions to form ultra-small coordination polymer nanodots (CPNs) with good water dispersibility and strong ROS scavenging ability. In particular, Fe–curcumin CPNs (Fe–Cur CPNs) are applied for cellular ROS scavenging and rhabdomyolysis-induced AKI relief.Keywords
Funding Information
- National Natural Science Foundation of China (U20A20254, 52072253, 51761145041)
- National Key Research and Development Program of China (2016YFA0201200)
- Israel Science Foundation (533/172)
- Collaborative Innovation Center of Suzhou Nano Science and Technology
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Soochow University
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