Syphilis infection does not affect immunodeficiency progression in HIV-infected men who have sex with men in China
- 11 March 2020
- journal article
- research article
- Published by SAGE Publications in International Journal of STD & AIDS
- Vol. 31 (5), 488-496
- https://doi.org/10.1177/0956462419860618
Abstract
Syphilis and human immunodeficiency virus (HIV) co-infection is expected to play a role in HIV-1-related immunodeficiency progression; however, studies involving syphilis/HIV co-infection have not been conclusive. We investigated the factors associated with co-infection of syphilis and HIV and to assess the effect of syphilis on HIV progression in the context of HIV-1 diversity in an observational cohort of 246 newly-diagnosed HIV-infected but antiretroviral therapy-naive men who have sex with men enrolled in Guangzhou, China between 2008 and 2012. CD4+ cell counts of all the participants were measured from the time of diagnosis until 2015 with an average of 32 ± 18 months. Logistic analysis indicated that patients with syphilis/HIV co-infection were more likely to be older with an adjusted odds ratio (AOR) of 2.48 (95% CI: 1.28–4.80) for those aged between 31 and 40 years and 3.20 (1.11–9.22) for those aged ≥40 years as compared to 16–30 year-olds. The AOR of patients infected with HIV-1 CRF07_BC as compared to CRF01_AE was 2.14 (95% CI: 1.01–4.53). Co-infection of syphilis and HIV was associated with lower baseline CD4+ cell count (0.45, 95% CI: 0.22–0.94), but was not associated with HIV disease progression (HR: 1.03; 95% CI, 0.86–1.23) based on Kaplan–Meier analysis. Our results provide new evidence about the interaction between syphilis and HIV and indicate differential rates of immunodeficiency progression as a function of HIV-1 genetic diversity.Keywords
Funding Information
- Bureau of Science and Information Technology of Guangzhou Municipality (No. 201704020219, 201707010184 and 201604020011)
This publication has 33 references indexed in Scilit:
- Slow immunological progression in HIV-1 CRF07_BC-infected injecting drug usersEmerging Microbes & Infections, 2013
- HIV and Syphilis Co-Infection Increasing among Men Who Have Sex with Men in China: A Systematic Review and Meta-AnalysisPLOS ONE, 2011
- Global Challenge of Antibiotic-Resistant Treponema pallidumAntimicrobial Agents and Chemotherapy, 2010
- Sexual Risk Taking, STI and HIV Prevalence Among Men Who Have Sex with Men in Six Indonesian CitiesAIDS and Behavior, 2009
- Selective Transmission of R5 HIV-1 over X4 HIV-1 at the Dendritic Cell–T Cell Infectious Synapse Is Determined by the T Cell Activation StatePLoS Pathogens, 2009
- Sexual practices, HIV and sexually transmitted infections among self-identified men who have sex with men in four high HIV prevalence states of IndiaAIDS, 2008
- Treponema pallidumElicits Innate and Adaptive Cellular Immune Responses in Skin and Blood during Secondary Syphilis: A Flow‐Cytometric AnalysisThe Journal of Infectious Diseases, 2007
- Different Rates of Disease Progression of HIV Type 1 Infection in Tanzania Based on Infecting SubtypeClinical Infectious Diseases, 2006
- Syphilis and Human Immunodeficiency Virus (HIV)-1 Coinfection: Influence on CD4 T-Cell Count, HIV-1 Viral Load, and Treatment ResponseSexually Transmitted Diseases, 2006
- 1993 Revised Classification System for HIV Infection and Expanded Surveillance Case Definition for AIDS Among Adolescents and AdultsClinical Infectious Diseases, 1993