Reduced 3‐year risk of hospital admission and mortality after 12‐week resistance training of cirrhosis patients: A follow‐up of a randomized clinical trial
Open Access
- 22 February 2023
- journal article
- research article
- Published by Wiley in Journal of Gastroenterology and Hepatology
- Vol. 38 (8), 1365-1371
- https://doi.org/10.1111/jgh.16141
Abstract
Background and AimPhysical activity confers health benefits in many diseases but remains almost unstudied for cirrhosis.We investigated whether a period of resistance training affects the subsequent long-term risk of hospitalization or mortality among patients with cirrhosis. MethodsThe study includes 39 participants with cirrhosis Child-Pugh class A/B who participated in a prior clinical trial randomized to either resistance training three times per week for 12 weeks or a control group. We gathered data through medical records from trial entry and the following 3 years. The outcomes were time to first hospitalization and all-cause mortality. We used regression models to examine the associations between trial groups and outcomes, adjusting for Child-Pugh class, age, gender, and comorbidity. ResultsNine patients who trained and 15 controls were hospitalized, resulting in a lower risk of first hospitalization in the training group (adjusted subdistribution hazard ratio of 0.40, 95% confidence interval [CI] [0.17, 0.92]; P = 0.03). One patient who trained and six controls died, resulting in a lower all-cause mortality in the training group (adjusted hazard ratio of 0.06, 95% CI [0.01, 0.66]; P = 0.02). ConclusionTwelve weeks of resistance training was associated with a reduced risk of first hospitalization and mortality among patients with cirrhosis Child-Pugh class A/B 3 years after trial entry. The mechanisms of this effect are not identified, and larger studies are warranted.Keywords
Funding Information
- Aase og Ejnar Danielsens Fond (10‐001650, 100.000)
- Beckett-Fonden (40552/40706, 100.000)
- Helsefonden (16‐B‐0133, 200.000)
- TrygFonden (108112, 1.548.961)
This publication has 27 references indexed in Scilit:
- Effects of an Exercise Programme on Functional Capacity, Body Composition and Risk of Falls in Patients with Cirrhosis: A Randomized Clinical TrialPLOS ONE, 2016
- Exercise as medicine – evidence for prescribing exercise as therapy in 26 different chronic diseasesScandinavian Journal of Medicine & Science in Sports, 2015
- Eight Weeks of Exercise Training Increases Aerobic Capacity and Muscle Mass and Reduces Fatigue in Patients With CirrhosisClinical Gastroenterology and Hepatology, 2014
- Randomized Pilot Study: Effects of an Exercise Programme and Leucine Supplementation in Patients with CirrhosisDigestive Diseases and Sciences, 2014
- Clinical relevance of sarcopenia in patients with cirrhosisWorld Journal of Gastroenterology, 2014
- Development and Validation of a Comorbidity Scoring System for Patients With CirrhosisGastroenterology, 2014
- Exercise-based cardiac rehabilitation for coronary heart diseasePublished by Wiley ,2011
- Infections in Patients With Cirrhosis Increase Mortality Four-Fold and Should Be Used in Determining PrognosisGastroenterology, 2010
- Physical Activity and Public Health in Older AdultsMedicine & Science in Sports & Exercise, 2007
- Heavy‐resistance training in older Scandinavian men and women: short‐ and long‐term effects on arm and leg musclesScandinavian Journal of Medicine & Science in Sports, 1995