Dengue and metabolomics in humans
- 12 March 2021
- journal article
- review article
- Published by Springer Science and Business Media LLC in Metabolomics
- Vol. 17 (3), 1-11
- https://doi.org/10.1007/s11306-021-01783-6
Abstract
Background Dengue virus causes dengue fever (DF)disease, transmitted by the mosquito Aedes aegypti. The symptoms could be severe and disable the affected individuals for weeks. The severe form, dengue hemorrhagic fever (DHF), can lead to death if not adequately attended to. Due to global warming, the vector mosquito will advance over new areas and expose more people to this disease over the next decades. Despite the severity, there are no treatments nor efficient vaccines available. Metabolomic studies have shown a new perspective to understand this disease better at a new molecular level. Aim of review Many published works rely on samples obtained from animal studies. This review will mainly focus on human samples and cell culture experiments to view how the dengue virus affects the metabolomic profile. Key scientific concepts of review The review compiles the sample sources, metabolomic techniques used, the detected compounds, and how they behave in different DF stages. This disease causes a significant change in many metabolites, but some results are still conflicting between studies. The results gathered here show that metabolomic approaches prove to be an excellent and viable way to expand knowledge about DF.This publication has 80 references indexed in Scilit:
- Serum Metabolome and Lipidome Changes in Adult Patients with Primary Dengue InfectionPLoS Neglected Tropical Diseases, 2013
- Refining the Global Spatial Limits of Dengue Virus Transmission by Evidence-Based ConsensusPLoS Neglected Tropical Diseases, 2012
- Metabolomics: the apogee of the omics trilogyNature Reviews Molecular Cell Biology, 2012
- Expanding Coverage of the Metabolome for Global Metabolite ProfilingAnalytical Chemistry, 2011
- Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesisProceedings of the National Academy of Sciences of the United States of America, 2010
- Dengue Virus Pathogenesis: an Integrated ViewClinical Microbiology Reviews, 2009
- Acute hepatic failure due to dengue: A case reportCases Journal, 2008
- Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapyNature Biotechnology, 2008
- Resolution of in flammation: state of the art, definitions and termsThe FASEB Journal, 2007
- FLAVIVIRUS GENOME ORGANIZATION, EXPRESSION, AND REPLICATIONAnnual Review of Microbiology, 1990