Genetic association study between TAB2 polymorphisms and noise-induced-hearing-loss in a Han Chinese population
Open Access
- 11 May 2021
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 16 (5), e0251090
- https://doi.org/10.1371/journal.pone.0251090
Abstract
Noise-induced-hearing-loss(NIHL) is a common occupational disease caused by various environmental and biological factors. To investigate the association between TAB2 and the susceptibility of NIHL of people exposed to occupational environments, a genetic association study was performed on selected companies with 588 cases and 537 healthy control subjects. Five selected single nucleotide polymorphisms (SNPs) in TAB2,incoluding rs2744434, rs521845, rs652921, rs7896, rs9485372, were genotyped after a collection of DNA samples. Evident differences in participants between the case group and the control group reveals the result that people with the TAB2 has a high probability of getting NIHL. The results show that rs521845 is deeply associated with the risk of NIHL and is available for the diagnosis in the future.Funding Information
- Six Talent Peaks Project in Jiangsu Province (WSW-017)
- Jiangsu Province’s Outstanding Medical Academic 5 Leader program (CXTDA2017029)
- Preventive Medicine Foundation of Jiangsu (Y2015049)
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