Plasminogen Receptors and Fibrinolysis
Open Access
- 8 February 2021
- journal article
- review article
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 22 (4), 1712
- https://doi.org/10.3390/ijms22041712
Abstract
The ability of cells to promote plasminogen activation on their surfaces is now well recognized, and several distinct cell surface proteins have been demonstrated to function as plasminogen receptors. Here, we review studies demonstrating that plasminogen bound to cells, in addition to plasminogen directly bound to fibrin, plays a major role in regulating fibrin surveillance. We focus on the ability of specific plasminogen receptors on eukaryotic cells to promote fibrinolysis in the in vivo setting by reviewing data obtained predominantly in murine models. Roles for distinct plasminogen receptors in fibrin surveillance in intravascular fibrinolysis, immune cell recruitment in the inflammatory response, wound healing, and lactational development are discussed.Funding Information
- National Institutes of Health (HL081046, HD101133, HL149511)
- U.S. Department of Veterans Affairs (I01BX003933)
- Familjen Erling-Perssons Stiftelse (1)
- the Cancer Research Foundation in Northern Sweden (1, 1)
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