Genomic Instability and Cellular Senescence: Lessons From the Budding Yeast
Open Access
- 12 January 2021
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Cell and Developmental Biology
Abstract
Ageing is a complex biological process that occurs in all living organisms. Ageing is initiated by the gradual accumulation of biomolecular damage in cells leading to the loss of cellular function and ultimately death. Cellular senescence is one such pathway that leads to ageing. The accumulation of nucleic acid damage and genetic alterations that activate permanent cell-cycle arrest triggers the process of senescence. Cellular senescence can result from telomere erosion and ribosomal DNA instability. In this review, we summarise the molecular mechanisms of telomere length homeostasis and ribosomal DNA stability, and describe how these mechanisms are linked to cellular senescence and longevity through lessons learned from budding yeast.Keywords
Funding Information
- Universiti Sains Malaysia
This publication has 128 references indexed in Scilit:
- Mechanism for priming DNA synthesis by yeast DNA Polymerase αeLife, 2013
- Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancerEMBO Molecular Medicine, 2012
- RPA facilitates telomerase activity at chromosome ends in budding and fission yeastsThe EMBO Journal, 2012
- DNA Replication through G-Quadruplex Motifs Is Promoted by the Saccharomyces cerevisiae Pif1 DNA HelicaseCell, 2011
- Regulation of ribosomal RNA gene copy number and its role in modulating genome integrity and evolutionary adaptability in yeastCellular and Molecular Life Sciences, 2011
- Reduced Rif2 and lack of Mec1 target short telomeres for elongation rather than double-strand break repairNature Structural & Molecular Biology, 2010
- Telomere capping in non-dividing yeast cells requires Yku and Rap1The EMBO Journal, 2010
- Rif1 and Rif2 Inhibit Localization of Tel1 to DNA EndsMolecular Cell, 2009
- Division of Labor at the Eukaryotic Replication ForkMolecular Cell, 2008
- Telomerase and Tel1p Preferentially Associate with Short Telomeres in S. cerevisiaeMolecular Cell, 2007