The article is focused on studying administrative and legal, bioethical issues of xenotransplantation in Ukraine. It has been emphasized that transplantation often remains the only alternative for preserving human life and health as the highest social values proclaimed in the Art. 3 of the Constitution of Ukraine. The importance of transplantation as a method of providing medical care is due to the fact that it involves in most cases the presence of two or more entities – a donor and a recipient. This fact stipulates additional requirements on its proper legal regulation, since it concerns the rights of more parties to such relations. It has been defined that xenotransplantation is a perspective vector for the development of medical science, which may compensate for the shortage of donor human anatomical materials in the nearest future. It has been established that the most important issue of xenotransplantation in Ukraine within the legal aspect should be the creation of appropriate legislative provision and appropriate amendments into the current national legislation. It has been emphasized that the main problem of xenotransplantation is the current reluctance of society to such medical innovations due to religious prohibitions, fear of public condemnation, own fears about the possible consequences of such intervention, etc. The authors have concluded that xenotransplantation in Ukraine needs proper legal regulation. It has been substantiated that the most appropriate solution is to approximate national legislation to the principles and guidelines set out in the Recommendations dated from June 19, 2003 No. Rec (2003) 10 “On Xenotransplantation”. The authors have emphasized on the importance of the in-depth discussion on issues related to the ethical aspect of xenotransplantation, in particular the formation of positive public opinion towards the participants of such a procedure and the admissibility of using anatomical materials of animals by human beings in general.