Clinical and Molecular Epidemiology of Extended-Spectrum Beta-Lactamase-Producing Escherichia Coli Infections in Metro Detroit: Early Dominance of the ST-131 Clone
Open Access
- 18 July 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Infectious Diseases and Therapy
- Vol. 9 (3), 683-690
- https://doi.org/10.1007/s40121-020-00321-6
Abstract
Introduction Extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli infections have become endemic worldwide. We aimed to describe the molecular and clinical epidemiology of ESBL-producing E. coli infections during a period of rising global prevalence. Methods Three hundred sixty-nine consecutive ESBL-producing E. coli infections in Detroit from 2010–2011 were analyzed. Sequence typing (ST) and CH typing were performed. Clinical characteristics and outcomes were compared between patients infected with ST131 and non-ST131 isolates. Results Ninety-six percent of isolates were ST 131, and 78.6% of ST 131 isolates produced blaCTX-M-15. Median time to effective therapy was 48 h vs. 35 h (P = 0.38) in the ST131 vs. non-ST131 groups. Ninety-day mortality rates (8% vs. 8%, P = 1.0) were similar between the two groups. Conclusion blaCTX-M-15 ST131 E. coli predominated in Detroit during an early period of global ST131 dissemination. Patients with ST131 E. coli infections had similar clinical outcomes to those with non-ST131 E. coli infections.Funding Information
- National Institute of Allergy and Infectious Diseases (R01-AI119446-01)
- Merck
This publication has 18 references indexed in Scilit:
- Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae: Update on Molecular Epidemiology and Treatment OptionsDrugs, 2019
- Global Extraintestinal Pathogenic Escherichia coli (ExPEC) LineagesClinical Microbiology Reviews, 2019
- Epidemic Emergence in the United States of Escherichia coli Sequence Type 131- H 30 (ST131- H 30), 2000 to 2009Antimicrobial Agents and Chemotherapy, 2017
- The Role of Epidemic Resistance Plasmids and International High-Risk Clones in the Spread of Multidrug-Resistant EnterobacteriaceaeClinical Microbiology Reviews, 2015
- Editorial Commentary: Flying Under the Radar: The Stealth Pandemic of Escherichia coli Sequence Type 131Clinical Infectious Diseases, 2013
- Epidemiology and Risk Factors for Isolation of Escherichia coli Producing CTX-M-Type Extended-Spectrum β-Lactamase in a Large U.S. Medical CenterAntimicrobial Agents and Chemotherapy, 2013
- Abrupt Emergence of a Single Dominant Multidrug-Resistant Strain of Escherichia coliThe Journal of Infectious Diseases, 2013
- Community-Associated Extended-Spectrum β-Lactamase–Producing Escherichia coli Infection in the United StatesClinical Infectious Diseases, 2012
- Intercontinental emergence of Escherichia coli clone O25:H4-ST131 producing CTX-M-15Journal of Antimicrobial Chemotherapy, 2007
- Genotypic analyses of uropathogenic Escherichia coli based on fimH single nucleotide polymorphisms (SNPs)Journal of Medical Microbiology, 2007