Concentration-driven phase transition and self-assembly in drying droplets of diluting whole blood
Open Access
- 3 November 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Scientific Reports
- Vol. 10 (1), 1-12
- https://doi.org/10.1038/s41598-020-76082-6
Abstract
Multi-colloidal systems exhibit a variety of structural and functional complexity owing to their ability to interact amongst different components into self-assembled structures. This paper presents experimental confirmations that reveal an interesting sharp phase transition during the drying state and in the dried film as a function of diluting concentrations ranging from 100% (undiluted whole blood) to 12.5% (diluted concentrations). An additional complementary contact angle measurement exhibits a monotonic decrease with a peak as a function of drying. This peak is related to a change in visco-elasticity that decreases with dilution, and disappears at the dilution concentration for the observed phase transition equivalent to 62% (v/v). This unique behavior is clearly commensurate with the optical image statistics and morphological analysis; and it is driven by the decrease in the interactions between various components within this bio-colloid. The implications of these phenomenal systems may address many open-ended questions of complex hierarchical structures.This publication has 42 references indexed in Scilit:
- Volume overload correlates with cardiovascular risk factors in patients with chronic kidney diseaseKidney International, 2014
- Influence of Substrate Nature on the Evaporation of a Sessile Drop of BloodJournal of Heat Transfer, 2012
- Pattern formation in drying drops of bloodJournal of Fluid Mechanics, 2010
- Allogeneic Hematopoietic Stem-Cell Transplantation for Sickle Cell DiseaseThe New England Journal of Medicine, 2009
- Mechanisms and models of the dehydration self-organization in biological fluidsPhysics-Uspekhi, 2004
- On the existence of regular structures in liquid human blood serum (plasma) and phase transitions in the course of its dryingTechnical Physics, 2003
- A change in the physical state of a nonequilibrium blood plasma protein film in patients with carcinomaTechnical Physics, 2002
- Phase transitions in liquid crystalsPhysics Reports, 2000
- Membrane phase transition of intact human platelets: Correlation with cold-induced activationJournal of Cellular Physiology, 1996
- The Scanning Electron Microscopy of Normal Human Peripheral Blood LymphocytesBritish Journal of Haematology, 1976