IL-10-1082 A>G (rs1800896) polymorphism confers susceptibility to pulmonary tuberculosis in Caucasians but not in Asians and Africans: a meta-analysis

Abstract

Background: Earlier studies have shown that interlukin-10 ( IL-10 ) -1082 A>G gene polymorphism is implicated in susceptibility to Pulmonary tuberculosis (PTB), but their results are inconsistent and inconclusive. In this study, a meta-analysis was performed to analyze the potential association between IL-10 -1082 A>G gene polymorphism and PTB susceptibility. Methods: A quantitative synthesis was done using PubMed (Medline), EMBASE and Google Scholar web-databases search and meta-analysis was performed by calculating pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) for all the genetic models. Results: A total of 22 eligible studies comprising 4956 PTB cases and 6428 healthy controls were included in the analysis. We did not observe any increased or decreased risk of PTB in allelic contrast (G vs. A: p=0.985; OR=1.001, 95% CI=0.863 to 1.162), homozygous (GG vs. AA: p=0.889; OR=1.029, 95% CI=0.692 to 1.529), heterozygous (GA vs. AA: p=0.244; OR=0.906, 95% CI=0.767 to 1.070), dominant (GG+AG vs. AA: p=0.357; OR=1.196, 95% CI=0.817 to 1.752) and recessive (GG vs. AA+AG: p=0.364; OR=0.921, 95% CI=0.771 to 1.100) genetic models. Likewise, no association of IL-10 -1082 A>G polymorphism with PTB risk was observed in Asian and African population for all the genetic models. Interestingly, the dominant model (GG+AG vs. AA: p=0.004; OR=1.694, 95% CI=1.183 to 2.425) demonstrated increased risk of PTB in Caucasian population. Conclusions: This meta-analysis concludes that IL-10 -1082 A>G gene polymorphism is not significantly associated with overall, Asian and African population. However, this polymorphism is associated with Caucasian population.