Membrane and organelle dynamics during cell division
- 7 February 2020
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Molecular Cell Biology
- Vol. 21 (3), 151-166
- https://doi.org/10.1038/s41580-019-0208-1
Abstract
During division, eukaryotic cells undergo a dramatic, complex and coordinated remodelling of their cytoskeleton and membranes. For cell division to occur, chromosomes must be segregated and new cellular structures, such as the spindle apparatus, must be assembled. Pre-existing organelles, such as the nuclear envelope, endoplasmic reticulum and Golgi apparatus, must be disassembled or remodelled, distributed and reformed. Smaller organelles such as mitochondria as well as cytoplasmic content must also be properly distributed between daughter cells. This mixture of organelles and cytoplasm is bound by a plasma membrane that is itself subject to remodelling as division progresses. The lipids resident in these different membrane compartments play important roles in facilitating the division process. In recent years, we have begun to understand how membrane remodelling is coordinated during division; however, there is still much to learn. In this Review, we discuss recent insights into how these important cellular events are performed and regulated. During cell division, the distribution of membrane-bound organelles needs to be tightly regulated to ensure the proper composition and function of daughter cells. Recent studies have shed light on the range of complex and dynamic mechanisms needed to mediate organelle inheritance and membrane remodelling during cell division.Keywords
This publication has 236 references indexed in Scilit:
- ER network formation requires a balance of the dynamin-like GTPase Sey1p and the Lunapark family member Lnp1pNature, 2012
- Repo-Man Coordinates Chromosomal Reorganization with Nuclear Envelope Reassembly during Mitotic ExitDevelopmental Cell, 2011
- RALA and RALBP1 regulate mitochondrial fission at mitosisNature, 2011
- Inhibition of Glycosphingolipid Biosynthesis Induces Cytokinesis FailureJournal of the American Chemical Society, 2011
- Mechanisms Determining the Morphology of the Peripheral ERCell, 2010
- The extended PP1 toolkit: designed to create specificityTrends in Biochemical Sciences, 2010
- A Comprehensive Comparison of Transmembrane Domains Reveals Organelle-Specific PropertiesCell, 2010
- A Class of Dynamin-like GTPases Involved in the Generation of the Tubular ER NetworkCell, 2009
- Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegansNature, 2005
- Ran Induces Spindle Assembly by Reversing the Inhibitory Effect of Importin α on TPX2 ActivityCell, 2001