Clinical outcomes of otogenic skull base osteomyelitis
- 1 August 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in European Archives of Oto-Rhino-Laryngology
- Vol. 278 (8), 2817-2822
- https://doi.org/10.1007/s00405-020-06366-0
Abstract
Purpose Skull base osteomyelitis (SBO) is an uncommon and a potentially life-threatening condition if not promptly recognized and properly treated. The aim of our study was to present a 32-case series of patients diagnosed with SBO at a single center. Methods In this retrospective study, we reviewed the data of patients diagnosed with otogenic SBO between January 2011 and January 2020. 32 patients were enrolled in the study. SBO diagnosis was based on a combination of symptoms and physical examination, bone scan, brain magnetic resonance imaging, and pathologic examination findings. The following clinical data were collected during the follow-up period: types of antibiotics used, duration of antibiotic treatment, C-reactive protein level, presence of disease control, duration from the onset of symptoms to diagnosis, and patient survival. Results The mean follow-up period was 11 (1-110) months. The mean duration of antibiotic treatment was 115 (19-223) days. The mean C-reactive protein levels at the time of diagnosis and at the endpoint of follow-up were 3.05 (0.56-18.31) and 0.21 (0.03-33.61) mg/dL, respectively (P < 0.001). Disease control rate was 34.9% at 1-year and 83.7% at 5-year follow-up. Patient survival rate was 90.6% at 1- and 3-year follow-ups. At the endpoint of follow-up, three patients died. The mean durations from the onset of symptoms to diagnosis were 50 (5-360) and 90 (30-480) days in patients with the controlled disease and in those with the uncontrolled disease, respectively, at the endpoint of follow-up (P = 0.043). Conclusion Comprehensive assessment and aggressive treatment of patients exhibiting symptoms suggestive of SBO would help in the rapid diagnosis of otogenic SBO, resulting in an improvement in prognosis.Funding Information
- the National Research Foundation of Korea (2018R1C1B6007775)
This publication has 9 references indexed in Scilit:
- A comprehensive review of skull base osteomyelitis: Diagnostic and therapeutic challenges among various presentationsAsian Journal of Neurosurgery, 2018
- Analysis of Prognostic Factors in Malignant External OtitisClinical and Experimental Otorhinolaryngology, 2017
- Central skull base osteomyelitisThe Laryngoscope, 2013
- Malignant External OtitisOtolaryngology -- Head and Neck Surgery, 2011
- Skull Base Osteomyelitis: The Effect of Comorbid Disease on HospitalizationThe Laryngoscope, 2008
- Otogenic Cranial Base OsteomyelitisOtology & Neurotology, 2008
- Necrotizing External OtitisOtology & Neurotology, 2007
- Skull Base OsteomyelitisOtolaryngologic Clinics of North America, 1996
- Malignant external otitisThe Laryngoscope, 1968