Different clinical relevance of anti-citrullinated proteins antibodies in RA patients
Open Access
- 14 May 2022
- journal article
- Published by Mediar Press in Rheumatology Science and Practice
- Vol. 60 (2), 181-187
- https://doi.org/10.47360/1995-4484-2022-181-187
Abstract
Objective – to find a potential relationship between ACPA and disease activity, bone destruction, and ACPAs responses to various therapeutic regimens.Materials and methods. The study included 232 patients with rheumatoid arthritis (RA); 90 patients had early RA; 142 patients had advanced stage of the disease.Results. 77 (85.6%) patients with early RA were high positive for anti-CCP, and 29 (70.7%) patients – high positive for anti-MCV. A positive correlation was found between anti-MCV and DAS28 (r=0.4; p=0.04). As for advanced RA, 78 (80.4%) patients were high positive for anti-CCP, and 70 (79.5%) – for anti-MCV. There was a positive correlation between anti-MCV concentration and SDAI (r=0.4; p=0.02), as well as CDAI (r=0.4; p=0.02). No significant correlations were found between the anti-CCP levels and activity indices, anti-CCP and acute-phase parameters in both early and advanced RA groups. Higher total Sharp scores (96.5 (65.0–122.0)) were found in pts high positive for anti-MCV (n=79), compared to low-positive/negative (n=27) patients (57.0 (31.0–88.0); pConclusion. Anti-MCV levels correlated with inflammatory activity and development of bone destruction, and were decreasing in pts on treatment. Anti-CCP was less responsive, showed minor changes during treatment, therefore its’ thorough monitoring was not feasible.Keywords
This publication has 37 references indexed in Scilit:
- NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid ArthritisScience Translational Medicine, 2013
- Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentinJCI Insight, 2012
- The influence of ACPA status and characteristics on the course of RANature Reviews Rheumatology, 2012
- Prediction of radiographic progression in rheumatoid arthritis and the role of antibodies against mutated citrullinated vimentin: results from a 10-year prospective studyAnnals Of The Rheumatic Diseases, 2009
- Rheumatoid arthritisThe Lancet, 2009
- Different properties of ACPA and IgM-RF derived from a large dataset: further evidence of two distinct autoantibody systemsArthritis Research & Therapy, 2009
- Rituximab therapy in Greek patients with rheumatoid arthritisBiologics: Targets and Therapy, 2008
- Antibodies to mutated citrullinated vimentin for diagnosing rheumatoid arthritis in anti-CCP-negative patients and for monitoring infliximab therapyArthritis Research & Therapy, 2008
- Mutation and citrullination modifies vimentin to a novel autoantigen for rheumatoid arthritisArthritis & Rheumatism, 2007
- Changes in macrophage function after rituximab treatment in patients with rheumatoid arthritisAnnals Of The Rheumatic Diseases, 2007