Importance and Difficulty of Differentiating BMA-induced AFF Prodromal Symptoms from Hormonal Therapy-related Femoral Pain
Open Access
- 15 March 2020
- journal article
- research article
- Published by Japanese Society of Internal Medicine in Internal Medicine
- Vol. 59 (6), 855-857
- https://doi.org/10.2169/internalmedicine.3157-19
Abstract
We herein report a case of breast cancer in a 74-year-old woman treated with exemestane as fourth-line hormonal therapy and bone-modifying agents for long time. She suddenly developed a right femoral shaft fracture during treatment. Her femoral fracture had a beaking sign on radiogram. Given this finding, her fracture was ultimately diagnosed as atypical femoral fracture (AFF). In this case, it was difficult to recognize the difference between groin pain as a prodromal symptom of AFF and that due to an adverse reaction to hormonal therapy. Therefore, clinicians should recognize the difficulty of this differentiation and consider the situation with caution.Keywords
This publication has 15 references indexed in Scilit:
- Atypical femoral fracture after receiving antiresorptive drugs in breast cancer patients with bone metastasis.Breast Cancer, 2016
- Fulvestrant 500 mg versus anastrozole 1 mg for hormone receptor-positive advanced breast cancer (FALCON): an international, randomised, double-blind, phase 3 trialThe Lancet, 2016
- Prodromal Symptoms in Patients with Bisphosphonate-Associated Atypical Fractures of the FemurJournal of Bone and Mineral Metabolism, 2014
- Atypical Subtrochanteric and Diaphyseal Femoral Fractures: Second Report of a Task Force of the American Society for Bone and Mineral ResearchJournal of Bone and Mineral Research, 2013
- Incidence of atypical nontraumatic diaphyseal fractures of the femurJournal of Bone and Mineral Research, 2012
- Incidence and demography of femur fractures with and without atypical featuresJournal of Bone and Mineral Research, 2012
- Nonoperative versus Prophylactic Treatment of Bisphosphonate-associated Femoral Stress FracturesClinical Orthopaedics and Related Research, 2011
- [Morphological analysis of bone dynamics and metabolic bone disease. Does bisphosphonate treatment cause severely suppressed bone turnover (SSBT) ?].2011
- Severely Suppressed Bone Turnover: A Potential Complication of Alendronate TherapyJournal of Clinical Endocrinology & Metabolism, 2005
- Anastrozole is superior to tamoxifen as first-line therapy in hormone receptor positive advanced breast carcinomaCancer, 2001