Exosomes for Diagnosis and Therapy in Gastrointestinal Cancers
Open Access
- 6 January 2020
- journal article
- review article
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 21 (1), 367
- https://doi.org/10.3390/ijms21010367
Abstract
Exosomes are membrane-bound extracellular vesicles (EVs) released by most cells, having a size ranging from 30 to 150 nm, and are involved in mechanisms of cell-cell communication in physiological and pathological tissues. Exosomes are engaged in the transport of biomolecules, such as lipids, proteins, messenger RNAs, and microRNA, and in signal transmission through the intercellular transfer of components. In the context of proteins and nucleic acids transported from exosomes, our interest is focused on the Frizzled proteins family and related messenger RNA. Exosomes can regenerate stem cell phenotypes and convert them into cancer stem cells by regulating the Wnt pathway receptor family, namely Frizzled proteins. In particular, for gastrointestinal cancers, the Frizzled protein involved in those mechanisms is Frizzled-10 (FZD-10). Currently, increasing attention is being devoted to the protein and lipid composition of exosomes interior and membranes, representing profound knowledge of specific exosomes composition fundamental for their application as new delivering drug tools for cancer therapy. This review intends to cover the most recent literature on the use of exosome vesicles for early diagnosis, follow-up, and the use of these physiological nanovectors as drug delivery systems for gastrointestinal cancer therapy.Keywords
This publication has 84 references indexed in Scilit:
- Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through METNature Medicine, 2012
- Intercellular communication: diverse structures for exchange of genetic informationNature Reviews Molecular Cell Biology, 2012
- The ESCRT machineryCurrent Biology, 2012
- Structural-Mechanical Characterization of Nanoparticle Exosomes in Human Saliva, Using Correlative AFM, FESEM, and Force SpectroscopyACS Nano, 2010
- Atomic force microscopy: a novel approach to the detection of nanosized blood microparticlesJournal of Thrombosis and Haemostasis, 2010
- Colorectal Cancer Epidemiology: Incidence, Mortality, Survival, and Risk FactorsClinics in Colon and Rectal Surgery, 2009
- A Lumenal Domain-Dependent Pathway for Sorting to Intralumenal Vesicles of Multivesicular Endosomes Involved in Organelle MorphogenesisDevelopmental Cell, 2006
- Fatty Acid Synthase Hyperactivation in Human Colorectal Cancer: Relationship with Tumor Side and SexOncology, 2006
- High‐level expression of fatty acid synthase in human prostate cancer tissues is linked to activation and nuclear localization of Akt/PKBThe Journal of Pathology, 2005
- Differences in serum tumor markers between colon and rectal cancerDiseases of the Colon & Rectum, 1996