Use of three-dimensional printing of a lumbar skeletal model for intrathecal administration of nusinersen: a brief technical report
- 1 October 2020
- journal article
- research article
- Published by BMJ in Regional Anesthesia & Pain Medicine
- Vol. 45 (10), 757-760
- https://doi.org/10.1136/rapm-2020-101607
Abstract
YySpinal muscular atrophy (SMA) is an autosomal recessive hereditary neurodegenerative disease causing progressive muscle atrophy, weakness and kyphoscoliosis. Nusinersen is a therapeutic agent for SMA that should be administered intrathecally. However, due to severe kyphoscoliosis, lumbar puncture can be challenging. Here, we present our experience of intrathecal administration of nusinersen in an SMA patient with severe kyphoscoliosis using a life--size three-dimensional printing (3D) skeletal model created with 3D printer. With this strategy, we were able to rapidly and safely perform the lumbar puncture.Funding Information
- JSPS KAKENHI (19H03749)
This publication has 16 references indexed in Scilit:
- Does Three-Dimensional Printed Patient-Specific Templates Add Benefit in Revision Surgeries for Complex Pediatric Kyphoscoliosis Deformity with Sublaminar Wires in Situ? A Clinical StudyAsian Spine Journal, 2021
- Three-dimensional printing in structural heart disease and interventionAnnals of Translational Medicine, 2019
- Feasibility and safety of intrathecal treatment with nusinersen in adult patients with spinal muscular atrophyTherapeutic Advances in Neurological Disorders, 2018
- A comprehensive institutional overview of intrathecal nusinersen injections for spinal muscular atrophyPediatric Radiology, 2018
- Current status of 3D printing in spine surgeryJournal of Clinical Orthopaedics and Trauma, 2018
- Nusinersen versus Sham Control in Infantile-Onset Spinal Muscular AtrophyThe New England Journal of Medicine, 2017
- Precise treatment of aortic aneurysm by three-dimensional printing and simulation before endovascular interventionScientific Reports, 2017
- Three-dimensional printing of surgical anatomyCurrent Opinion in Urology, 2016
- Clinical application of 3D pre-bent titanium implants for orbital floor fracturesJournal of Cranio-Maxillofacial Surgery, 2009
- Spinal muscular atrophyThe Lancet, 2008