Origin of the MRI Contrast in Natural and Hydrogel Formulation of Pineapple Juice
Open Access
- 5 January 2021
- journal article
- research article
- Published by Hindawi Limited in Bioinorganic Chemistry and Applications
- Vol. 2021, 1-12
- https://doi.org/10.1155/2021/6666018
Abstract
Magnetic resonance imaging (MRI) often requires contrast agents to improve the visualization in some tissues and organs, including the gastrointestinal tract. In this latter case, instead of intravascular administration, oral agents can be used. Natural oral contrast agents, such as fruit juice, have the advantages of better taste, tolerability, and lower price with respect to the artificial agents. We have characterized the relaxometry profiles of pineapple juice in order to understand the origin of the increase in relaxation rates (and thus of the MRI contrast) in reference to its content of manganese ions. Furthermore, we have characterized the relaxometry profiles of pineapple juice in the presence of alginate in different amounts; the interaction of the manganese ions with alginate slows down their reorientation time to some extent, with a subsequent increase in the relaxation rates. The relaxometry profiles were also compared with those of manganese(II) solutions in 50mmol/dm3 sodium acetate solution (same pH of pineapple juice), which revealed sizable differences, mostly in the number of water molecules coordinated to the metal ion, their lifetimes, and in the constant of the Fermi-contact interaction. Finally, the fit of the transverse relaxivity shows that the increased viscosity in the hydrogel formulations can improve significantly the negative contrast of pineapple juice at the magnetic fields relevant for clinical MRI.Keywords
Funding Information
- Fondazione Cassa di Risparmio di Firenze
This publication has 44 references indexed in Scilit:
- Hydrogels Incorporating GdDOTA: Towards Highly Efficient Dual T1/T2 MRI Contrast AgentsAngewandte Chemie, 2012
- Alginate: Properties and biomedical applicationsProgress in Polymer Science, 2012
- Clinical Feasibility of Açai (Euterpe olerácea) Pulp as an Oral Contrast Agent for Magnetic Resonance CholangiopancreatographyJournal of Computer Assisted Tomography, 2009
- Albumin Binding, Relaxivity, and Water Exchange Kinetics of the Diastereoisomers of MS-325, a Gadolinium(III)-Based Magnetic Resonance Angiography Contrast AgentInorganic Chemistry, 2007
- Relaxometric and Modelling Studies of the Binding of a Lipophilic Gd-AAZTA Complex to Fatted and Defatted Human Serum AlbuminChemistry – A European Journal, 2007
- Pineapple juice as a negative oral contrast agent in magnetic resonance cholangiopancreatography: a preliminary evaluationThe British Journal of Radiology, 2004
- Manganese in pineapple juicesFood Chemistry, 2000
- Metal-Containing Components in Medicinal Plants. III. Manganese-Containing Components in Theae Folium as Oral Magnetic Resonance Imaging Contrast Materials.CHEMICAL & PHARMACEUTICAL BULLETIN, 1996
- Nuclear and electron relaxation of hexaaquairon(3+)The Journal of Physical Chemistry, 1993
- Relaxation Processes in a System of Two SpinsPhysical Review B, 1955