SnSe Nanosheets Mimic Lactate Dehydrogenase to Reverse Tumor Acid Microenvironment Metabolism for Enhancement of Tumor Therapy
Open Access
- 5 December 2022
- Vol. 27 (23), 8552
- https://doi.org/10.3390/molecules27238552
Abstract
The acidic tumor microenvironment (TME) is unfriendly to the activity and function of immune cells in the TME. Here, we report inorganic nanozymes (i.e., SnSe NSs) that mimic the catalytic activity of lactate dehydrogenase to degrade lactate to pyruvate, contributing to the metabolic treatment of tumors. As found in this study, SnSe NSs successfully decreased lactate levels in cells and tumors, as well as reduced tumor acidity. This is associated with activation of the immune response of T cells, thus alleviating the immunosuppressive environment of the TME. More importantly, the nanozyme successfully inhibited tumor growth in mutilate mouse tumor models. Thus, SnSe NSs show a promising result in lactate depletion and tumor suppression, which exemplifies its potential strategy in targeting lactate for metabolic therapy.Funding Information
- Suzhou Key Laboratory of Nanotechnology and Biomedicine
- Collaborative Innovation Center of Suzhou Nano Science & Technology
- the 111 Project
- Joint International Research Laboratory of Carbon-Based Functional Materials and Devices
This publication has 28 references indexed in Scilit:
- Metabolic crosstalk in the breast cancer microenvironmentEuropean Journal of Cancer, 2019
- Metabolic regulation of gene expression by histone lactylationNature, 2019
- Macrophages and Metabolism in the Tumor MicroenvironmentCell Metabolism, 2019
- Lactate: A Metabolic Driver in the Tumour LandscapeTrends in Biochemical Sciences, 2019
- Tumour acidosis: from the passenger to the driver's seatNature Reviews Cancer, 2017
- LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK CellsCell Metabolism, 2016
- Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer ProgressionCell, 2015
- Functional polarization of tumour-associated macrophages by tumour-derived lactic acidNature, 2014
- Targeting lactate metabolism for cancer therapeuticsJCI Insight, 2013
- Interfering with pH regulation in tumours as a therapeutic strategyNature Reviews Drug Discovery, 2011