Responsive Degradable Theranostic Agents Enable Controlled Selenium Delivery to Enhance Photothermal Radiotherapy and Reduce Side Effects
- 28 February 2021
- journal article
- research article
- Published by Wiley in Advanced Healthcare Materials
- Vol. 10 (10), 2002024
- https://doi.org/10.1002/adhm.202002024
Abstract
Radiotherapy (RT) is a popular clinical therapy method for extending cancer patient survival, but is hampered by severe side effects and the weak therapy effect. Herein, responsive degradable selenium (Se) theranostic agents (Se@SiO2@Bi nanocomposites (NCs)) are fabricated, which combine computed tomography (CT) imaging and simultaneously enhance the therapeutic effects of photothermal therapy (PTT) and RT, while reducing the side effects of radiation. The Se@SiO2@Bi theranostic agents can accumulate at the tumor site, and responsively decompose to releease Se, avoiding systemic toxicity by the element. Se enhances the effect of PTT/RT, simultaneously reducing the side effects of RT. The Se@SiO2@Bi NCs as CT agents also exhibit significantly enhanced contrast imaging performance due to the high atomic number of Bi. More importantly, the Se@SiO2@Bi NCs can be rapidly excreted without long‐term toxicity, owing to responsive degradation into ultrasmall particles (2@Bi NCs can remarkably inhibit tumor cells, without causing appreciable toxicity during the treatment. This study opens a new perspective in rationally designing responsive degradable theranostic agents for future tumor therapy with enhanced therapeutic efficacy and lesser side effects.Keywords
Funding Information
- National Natural Science Foundation of China (21978165, 31701032)
This publication has 58 references indexed in Scilit:
- Facile synthesis of Bi2S3-MoS2 heterogeneous nanoagent as dual functional radiosensitizer for triple negative breast cancer theranosticsChemical Engineering Journal, 2020
- Full-Process Radiosensitization Based on Nanoscale Metal–Organic FrameworksACS Nano, 2020
- Bismuth‐Based Nanomaterials: Recent Advances in Tumor Targeting and Synergistic Cancer Therapy TechniquesAdvanced Healthcare Materials, 2020
- The versatile biomedical applications of bismuth-based nanoparticles and composites: therapeutic, diagnostic, biosensing, and regenerative propertiesChemical Society Reviews, 2020
- Rod-based urchin-like hollow microspheres of Bi2S3: Facile synthesis, photo-controlled drug release for photoacoustic imaging and chemo-photothermal therapy of tumor ablationBiomaterials, 2020
- Ultra-small Bi2S3 nanodot-doped reversible Fe(ii/iii)-based hollow mesoporous Prussian blue nanocubes for amplified tumor oxidative stress-augmented photo-/radiotherapyBiomaterials Science, 2020
- Biomolecules-assisted synthesis of degradable bismuth nanoparticles for dual-modal imaging-guided chemo-photothermal therapyChemical Engineering Journal, 2019
- Construct of MoSe2/Bi2Se3 nanoheterostructure: Multimodal CT/PT imaging-guided PTT/PDT/chemotherapy for cancer treatingBiomaterials, 2019
- A novel theranostic agent based on porous bismuth nanosphere for CT imaging-guided combined chemo-photothermal therapy and radiotherapyJournal of Materials Chemistry B, 2018
- Ultrasmall Semimetal Nanoparticles of Bismuth for Dual-Modal Computed Tomography/Photoacoustic Imaging and Synergistic ThermoradiotherapyACS Nano, 2017