Objective: To explore the multidisciplinary treatment for complications after pancreaticoduodenectomy. Methods: The clinical data of the patient after pancreaticoduodenectomy treated in the Eighth Affiliated Hospital of Sun Yat-sen University in March 2021 was analyzed retrospectively. The patient presented pancreatic leakage, chylous leakage, incisional dehiscence and infection, multi-drug resistance and infection combined with infectious shock after surgery. Results: The patient underwent pancreaticoduodenectomy in another hospital. After active anti-infective therapy, incisional negative pressure drainage and enteral and parenteral nutritional support, assisted by enzyme inhibition, supplementing human albumin, and correction of water-electrolyte and acid-base imbalance in our hospital, the patient was finally cured and discharged. Conclusion: The treatment of complications after pancreaticoduodenectomy is difficult and needs multidisciplinary cooperation.