Differences between COVID‐19 and suspected then confirmed SARS‐CoV‐2‐negative pneumonia: A retrospective study from a single center
- 1 April 2020
- journal article
- research article
- Published by Wiley in Journal of Medical Virology
- Vol. 92 (9), 1572-1579
- https://doi.org/10.1002/jmv.25810
Abstract
Coronavirus disease 2019 (COVID‐19) broke out in Wuhan, Hubei, China in December 2019. Tens thousands of people have been infected with the disease. Our aim was to distinguish severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)‐positive patients from SARS‐CoV‐2‐negative patients. We retrospectively compared the data of COVID‐19 patients with those of suspected and confirmed SARS‐CoV‐2‐negative patients (control patients). There were 78 COVID‐19 patients and 26 control patients, whose median ages were significantly different (P=0.001). The percentage of COVID‐19 patients admitting exposure to Wuhan was obviously higher than that of control patients (X2=29.130, PX2=22.636, P X2=24.930, 8.480, P <0.05).Younger age, exposure to Wuhan, fever, cough, and slight changes in routine blood work‐up parameters, urea and creatinine were important features discriminating COVID‐19 from control patients. Slightly increased, but far less than 0.5ng/ml, PCT levels also differentiated COVID‐19 patients from control patientsFunding Information
- Xianxiang Zhang (Project No.2020CDJYGRH-YJ03 to Xianxiang Zhang)
- Bo Han (Natural Science Foundation of China (Grants No. 81972416, 81672554, and 81472417 to Bo Han))
This publication has 12 references indexed in Scilit:
- Incubation Period and Other Epidemiological Characteristics of 2019 Novel Coronavirus Infections with Right Truncation: A Statistical Analysis of Publicly Available Case DataJournal of Clinical Medicine, 2020
- Clinical features of patients infected with 2019 novel coronavirus in Wuhan, ChinaThe Lancet, 2020
- Inflammatory markers in systemic lupus erythematosusJournal of Autoimmunity, 2019
- Epidemiology, pathogenesis, treatment and outcomes of infection-associated glomerulonephritisNature Reviews Nephrology, 2019
- Diagnostic and prognostic utilities of multimarkers approach using procalcitonin, B-type natriuretic peptide, and neutrophil gelatinase-associated lipocalin in critically ill patients with suspected sepsisBMC Infectious Diseases, 2014
- Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive studyThe Lancet Infectious Diseases, 2013
- Inflammation markers in point-of-care testing (POCT)Analytical and Bioanalytical Chemistry, 2008
- Acute renal impairment in coronavirus-associated severe acute respiratory syndromeKidney International, 2005
- Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirusNature, 2003